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CNS glia are crucial players in the onset of MS, primarily involving astrocytes and microglia that can cause\/allow massive oligodendroglial cells death, without immune cell infiltration. Current therapeutic approaches are aimed at modulating inflammatory reactions during relapsing episodes, but lack the ability to induce very significant repair mechanisms. In this review article, different experimental approaches based mainly on the application of different cell types as therapeutic strategies applied for the induction of myelin repair and\/or the amelioration of the disease are discussed. Regarding this issue, different cell sources were applied in various experimental models of MS, with different results, both in significant improvements in remyelination and the reduction of neuroinflammation and glial activation, or in neuroprotection. All cell types tested have advantages and disadvantages, which makes it difficult to choose a better option for therapeutic application in MS. New strategies combining cell\u2010based treatment with other applications would result in further improvements and would be good candidates for MS cell therapy and myelin repair.<\/jats:p>","DOI":"10.1002\/jnr.25129","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T02:36:04Z","timestamp":1664246164000},"page":"86-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cell\u2010based experimental strategies for myelin repair in multiple sclerosis"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9486-1028","authenticated-orcid":false,"given":"Maximiliano","family":"Borda","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones en Medicina Traslacional (IIMT) CONICET\u2010Universidad Austral  Derqui, Pilar, Buenos Aires 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