{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:11:59Z","timestamp":1772118719659,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T00:00:00Z","timestamp":1669420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The effects of MgSO\n                    <jats:sub>4<\/jats:sub>\n                    as an anti\u2010inflammatory agent in pregnant women have been investigated in the last few years. Infections can cause an inflammatory reaction involving the placenta membranes and amniotic cavity. They may have short\u2010term effects on the mother and her fetuses, like preterm birth, cerebral palsy, and developmental delay. Despite the alleged advantages of MgSO\n                    <jats:sub>4<\/jats:sub>\n                    as a neuroprotective agent in the preterm brain, the long\u2010term molecular and behavioral function of MgSO\n                    <jats:sub>4<\/jats:sub>\n                    has not been fully elucidated. Here, we investigated the long\u2010term effect of antenatal MgSO\n                    <jats:sub>4<\/jats:sub>\n                    , during late gestation, on offspring's behavior focusing on cognitive function, motor activity, and social cognition in adolescence and adulthood, and explored its influence on brain gene expression (e.g., ErbB signaling, pro\u2010inflammatory, and dopaminergic markers) in adulthood. A significant abnormal exploratory behavior of offspring of MgSO\n                    <jats:sub>4<\/jats:sub>\n                    \u2010treated dams was found compared to the control group in both adolescence and adulthood. Furthermore, we found that adult females exposed to MgSO\n                    <jats:sub>4<\/jats:sub>\n                    under inflammation displayed working and recognition memory impairment. A reduction in IL\u20106 expression was detected in the prefrontal cortex, and hippocampus specimens derived from LPS\u2013Mg\u2010treated group. In contrast, an imbalanced expression of dopamine 1 and 2 receptors was detected only in prefrontal cortex specimens. Besides, we found that MgSO\n                    <jats:sub>4<\/jats:sub>\n                    ameliorated the overexpression of the Nrg1 and Erbb4 receptors induced by LPS in the hippocampus. Thus, MgSO\n                    <jats:sub>4<\/jats:sub>\n                    treatment for preventing brain injuries can adversely affect offspring cognition behavior later in life, depending on the sex and age of the offspring.\n                  <\/jats:p>","DOI":"10.1002\/jnr.25148","type":"journal-article","created":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T17:01:24Z","timestamp":1669482084000},"page":"316-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010term effects of prophylactic\n                    <scp>\n                      MgSO\n                      <sub>4<\/sub>\n                    <\/scp>\n                    in maternal immune activation rodent model at adolescence and adulthood"],"prefix":"10.1002","volume":"101","author":[{"given":"Fadwa","family":"Dabbah\u2010Assadi","sequence":"first","affiliation":[{"name":"Psychobiology Research Laboratory Mazor Mental Health Center  Akko Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine Technion\u2014Israel Institute of Technology  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Engineering ORT Braude College  Karmiel Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idit","family":"Golani","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Engineering ORT Braude College  Karmiel Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alon","family":"Rubinstein","sequence":"additional","affiliation":[{"name":"Faculty of Medicine in the Galilee Bar\u2010Ilan University  Zefat Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravid","family":"Doron","sequence":"additional","affiliation":[{"name":"Department of Education and Psychology the Open University  Raanana Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Alon","sequence":"additional","affiliation":[{"name":"Psychobiology Research Laboratory Mazor Mental Health Center  Akko Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eilam","family":"Palzur","sequence":"additional","affiliation":[{"name":"The Neuroscience Laboratory Galilee Medical Center Research Institute  Nahariya Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Beloosesky","sequence":"additional","affiliation":[{"name":"The Ruth and Bruce Rappaport Faculty of Medicine Technion\u2014Israel Institute of Technology  Haifa Israel"},{"name":"Department of Obstetrics and Gynecology Rambam Medical Center  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8555-339X","authenticated-orcid":false,"given":"Alon","family":"Shamir","sequence":"additional","affiliation":[{"name":"Psychobiology Research Laboratory Mazor Mental Health Center  Akko Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine Technion\u2014Israel Institute of Technology  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,26]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"2","article-title":"Magnesium sulfate before anticipated preterm birth for neuroprotection","volume":"2010","author":"ACOG","year":"2010","journal-title":"ACOG Committee 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