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As opposed to efferent innervation, less is known about cardiac afferents. For this, we mapped the VGLUT2\u2010expressing cardiac afferent fibers of spinal and vagal origin by using the VGLUT2::tdTomato double transgenic mouse as an approach to visualize the whole hearts both at the dorsal and ventral sides. For comparison, we colabeled mixed\u2010sex transgenic hearts with either TUJ1 protein for global cardiac innervation or tyrosine hydroxylase for the sympathetic network at the healthy state or following ischemic injury. Interestingly, the nerve density for global and VGLUT2\u2010expressing afferents was found significantly higher on the dorsal side compared to the ventral side. From the global nerve innervation detected by TUJ1 immunoreactivity, VGLUT2 afferent innervation was detected to be 15\u201325% of the total network. The detailed characterization of both the atria and the ventricles revealed a remarkable diversity of spinal afferent nerve ending morphologies of flower sprays, intramuscular endings, and end\u2010net branches that innervate distinct anatomical parts of the heart. Using this integrative approach in a chronic myocardial infarct model, we showed a significant increase in hyperinnervation in the form of axonal sprouts for cardiac afferents at the infarct border zone, as well as denervation at distal sites of the ischemic area. The functional and physiological consequences of the abnormal sensory innervation remodeling post\u2010ischemic injury should be further evaluated in future studies regarding their potential contribution to cardiac dysfunction.<\/jats:p>","DOI":"10.1002\/jnr.25150","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T22:59:42Z","timestamp":1671058782000},"page":"338-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["High\u2010resolution mapping of sensory fibers at the healthy and post\u2010myocardial infarct whole transgenic hearts"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8701-1172","authenticated-orcid":false,"given":"Sevilay Goktas","family":"Sahoglu","sequence":"first","affiliation":[{"name":"Regenerative and Restorative Medical Research Center (REMER), Research Institute for Health Sciences and Technologies (SABITA) Istanbul Medipol University  Istanbul Turkey"},{"name":"Neuroscience Program, Institute of Health Sciences Istanbul Medipol University  Istanbul Turkey"},{"name":"Department of Medical Biology, School of Medicine Istanbul Medipol University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4610-9920","authenticated-orcid":false,"given":"Yusuf Enes","family":"Kazci","sequence":"additional","affiliation":[{"name":"Regenerative and Restorative Medical Research Center (REMER), Research Institute for Health Sciences and Technologies (SABITA) Istanbul Medipol University  Istanbul Turkey"},{"name":"Neuroscience Program, Institute of Health Sciences Istanbul Medipol University  Istanbul Turkey"},{"name":"Department of Medical Biology, International School of Medicine Istanbul Medipol University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2894-3735","authenticated-orcid":false,"given":"Behnaz","family":"Karadogan","sequence":"additional","affiliation":[{"name":"Regenerative and Restorative Medical Research Center (REMER), Research Institute for Health Sciences and Technologies (SABITA) Istanbul Medipol University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Serif","family":"Aydin","sequence":"additional","affiliation":[{"name":"Regenerative and Restorative Medical Research Center (REMER), Research Institute for Health Sciences and Technologies (SABITA) Istanbul Medipol University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2962-9836","authenticated-orcid":false,"given":"Aylin","family":"Nebol","sequence":"additional","affiliation":[{"name":"Regenerative and Restorative Medical Research Center (REMER), Research Institute for Health Sciences and Technologies (SABITA) Istanbul Medipol University  Istanbul Turkey"},{"name":"Department of Medical Biology, School of Medicine Istanbul Medipol University  Istanbul Turkey"},{"name":"Medical Biology and Genetics Program, Institute of Health Sciences Istanbul Medipol University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6219-124X","authenticated-orcid":false,"given":"Mehmet Ugurcan","family":"Turhan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Cerrahpasa School of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurkan","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Regenerative and Restorative Medical Research Center (REMER), Research Institute for Health Sciences and Technologies (SABITA) Istanbul Medipol University  Istanbul Turkey"},{"name":"Department of Physiology, International School of Medicine Istanbul Medipol University  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7199-583X","authenticated-orcid":false,"given":"Esra","family":"Cagavi","sequence":"additional","affiliation":[{"name":"Regenerative and Restorative Medical Research Center (REMER), Research Institute for Health Sciences and Technologies (SABITA) Istanbul Medipol University  Istanbul Turkey"},{"name":"Department of Medical Biology, School of Medicine Istanbul Medipol University  Istanbul Turkey"},{"name":"Department of Medical Biology, International School of Medicine Istanbul Medipol University  Istanbul Turkey"},{"name":"Medical Biology and Genetics Program, Institute of Health Sciences Istanbul Medipol University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2020.147201"},{"key":"e_1_2_14_3_1","unstructured":"Allen Institute for Brain Science. 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