{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:29:36Z","timestamp":1787974176075,"version":"build-2784847793"},"reference-count":94,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005191","name":"Craig H. Neilsen Foundation","doi-asserted-by":"publisher","award":["CHN36354"],"award-info":[{"award-number":["CHN36354"]}],"id":[{"id":"10.13039\/100005191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The immature central nervous system is recognized as having substantial neuroplastic capacity. In this study, we explored the hypothesis that rehabilitation can exploit that potential and elicit reciprocal walking in nonambulatory children with chronic, severe (i.e., lower extremity motor score\u2009&lt;\u200910\/50) spinal cord injuries (SCIs). Seven male subjects (3\u201312\u2009years of age) who were at least 1\u2010year post\u2010SCI and incapable of discrete leg movements believed to be required for walking, enrolled in activity\u2010based locomotor training (ABLT;\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                    NCT00488280). Six children completed the study. Following a minimum of 49 sessions of ABLT, three of the six children achieved walking with reverse rolling walkers. Stepping development, however, was not accompanied by improvement in discrete leg movements as underscored by the persistence of synergistic movements and little change in lower extremity motor scores. Interestingly, acoustic startle responses exhibited by the three responding children suggested preserved reticulospinal inputs to circuitry below the level of injury capable of mediating leg movements. On the other hand, no indication of corticospinal integrity was obtained with transcranial magnetic stimulation evoked responses in the same individuals. These findings suggest some children who are not predicted to improve motor and locomotor function may have a reserve of adaptive plasticity that can emerge in response to rehabilitative strategies such as ABLT. Further studies are warranted to determine whether a critical need exists to re\u2010examine rehabilitation approaches for pediatric SCI with poor prognosis for any ambulatory recovery.\n                  <\/jats:p>","DOI":"10.1002\/jnr.25162","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T22:53:46Z","timestamp":1674514426000},"page":"826-842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Recovery of walking in nonambulatory children with chronic spinal cord injuries: Case series"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7277-2550","authenticated-orcid":false,"given":"Dena R.","family":"Howland","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery Kentucky Spinal Cord Injury Research Center, University of Louisville  Louisville Kentucky USA"},{"name":"Research Service Robley Rex VA Medical Center  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley A.","family":"Trimble","sequence":"additional","affiliation":[{"name":"Spinal Cord Injury Outpatient Program, Pediatric NeuroRecovery Frazier Rehab Institute  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J.","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Florida  Gainesville Florida USA"},{"name":"Brooks Rehabilitation  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole J.","family":"Tester","sequence":"additional","affiliation":[{"name":"Movement Disorders &amp; Neurorestoration Program, Norman Fixel Institute for Neurological Sciences University of Florida Health  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3945-0282","authenticated-orcid":false,"given":"Martina R.","family":"Spiess","sequence":"additional","affiliation":[{"name":"ZHAW Zurich University of Applied Sciences, School of Health Sciences Institute of Occupational Therapy  Winterthur Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia R.","family":"Senesac","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Kleim","sequence":"additional","affiliation":[{"name":"School of Biological and Health Systems Engineering &amp; Ira A. 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