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It is the principal source of cerebrospinal fluid (CSF) and responsible for the synthesis and secretion of various neuroprotective peptides including those involved in amyloid\u2010\u03b2 (A\u03b2) transport\/degradation, contributing to A\u03b2 homeostasis. Inadequate A\u03b2 metabolic clearance and transport across the BCSFB have been associated with circadian dysfunctions in Alzheimer's disease (AD) patients. To investigate whether AD pathology influences A\u03b2 scavengers circadian expression, we collected CP at different time points from an AD mouse model (APP\/PS1) (female and male animals, aged 6\u2010 and 12\u2010months\u2010old) and analyzed their mRNA expression by Real\u2010time RT\u2010PCR. Only angiotensin\u2010converting enzyme (Ace) expression in 6\u2010month\u2010old female wild\u2010type mice and transthyretin (Ttr) expression in 12\u2010month\u2010old female wild\u2010type mice presented significant rhythmicity. The circadian rhythmicity of Ace and Ttr, prompt us to analyze the involvement of circadian rhythm in A\u03b2 uptake. A human CP papilloma (HIBCPP) cell line was incubated with A\u03b2\u2010488 and uptake was evaluated at different time points using flow cytometry. A\u03b2 uptake displayed circadian rhythmicity. Our results suggest that AD might affect A\u03b2 scavengers rhythmicity and that A\u03b2 clearance is a rhythmic process possibly regulated by the rhythmic expression of A\u03b2 scavengers.<\/jats:p>","DOI":"10.1002\/jnr.25164","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T04:31:09Z","timestamp":1672374669000},"page":"524-540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Circadian rhythmicity of amyloid\u2010beta\u2010related molecules is disrupted in the choroid plexus of a female Alzheimer's disease mouse model"],"prefix":"10.1002","volume":"101","author":[{"given":"Andr\u00e9","family":"Furtado","sequence":"first","affiliation":[{"name":"CICS\u2010UBI, Health Sciences Research Centre, University of Beira Interior  Covilh\u00e3 Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 J.","family":"Esgalhado","sequence":"additional","affiliation":[{"name":"CICS\u2010UBI, Health Sciences Research Centre, University of Beira Interior  Covilh\u00e3 Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5911-6521","authenticated-orcid":false,"given":"Ana C.","family":"Duarte","sequence":"additional","affiliation":[{"name":"CICS\u2010UBI, Health Sciences Research Centre, University of Beira Interior  Covilh\u00e3 Portugal"},{"name":"UDI\u2010IPG\u2010 Unidade de Investiga\u00e7\u00e3o para o Desenvolvimento do Interior Instituto Polit\u00e9cnico da Guarda  Guarda Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana R.","family":"Costa","sequence":"additional","affiliation":[{"name":"CICS\u2010UBI, Health Sciences Research Centre, University of Beira Interior  Covilh\u00e3 Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana R.","family":"Costa\u2010Brito","sequence":"additional","affiliation":[{"name":"CICS\u2010UBI, Health Sciences Research Centre, University of Beira Interior  Covilh\u00e3 Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Carro","sequence":"additional","affiliation":[{"name":"Networked Biomedical Research Center in Neurodegenerative Diseases (CIBERNED)  Madrid Spain"},{"name":"Group of Neurodegenerative Diseases Hospital 12 de Octubre Research Institute (imas12)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Regenerative Medicine, Department of Neurosurgery, Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"Schroten","sequence":"additional","affiliation":[{"name":"Mannheim Medical Faculty University of Heidelberg, Childrens Hospital  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1706-0259","authenticated-orcid":false,"given":"Christian","family":"Schwerk","sequence":"additional","affiliation":[{"name":"Mannheim Medical Faculty University of Heidelberg, Childrens Hospital  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"CICS\u2010UBI, Health Sciences Research Centre, University of Beira Interior  Covilh\u00e3 Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7209-4507","authenticated-orcid":false,"given":"Fernando A.","family":"Arosa","sequence":"additional","affiliation":[{"name":"CICS\u2010UBI, Health Sciences Research Centre, University of Beira Interior  Covilh\u00e3 Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cec\u00edlia R. 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