{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T13:18:45Z","timestamp":1788095925528,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,19]],"date-time":"2023-02-19T00:00:00Z","timestamp":1676764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000887","name":"Huntington's Disease Society of America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000887","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Individuals with pre\u2010manifest and early symptomatic Huntington's disease (HD) have shown deficits in solving arithmetic word\u2010problems. However, the neural correlates of these deficits in HD are poorly understood. We explored the structural (gray\u2010matter volume; GMV) and metabolic (18F\u2010FDG PET; SUVr) brain correlates of arithmetic performance using the recently developed HD\u2010word problem arithmetic task (HD\u2010WPA) in seventeen preHD and sixteen HD individuals. Symptomatic participants showed significantly lower scores in the HD\u2010WPA than preHD participants. Lower performance in the HD\u2010WPA was associated with reduced GMV in subcortical, medial frontal, and several posterior\u2010cortical clusters in HD participants. No significant GMV loss was found in preHD participants. 18F\u2010FDG data revealed a widespread pattern of hypometabolism in association with lower arithmetic performance in all participants. In preHD participants, this pattern was restricted to the ventrolateral and orbital prefrontal cortex, the insula, and the precentral gyrus. In HD participants, the pattern extended to several parietal\u2013temporal regions. Word\u2010problem solving arithmetic deficits in HD is subserved by a pattern of asynchronous metabolic and structural compromise across the cerebral cortex as a function of disease stage. In preHD individuals, arithmetic deficits were associated with prefrontal alterations, whereas in symptomatic HD patients, more severe arithmetic deficits are associated with the compromise of several frontal\u2010subcortical and temporo\u2010parietal regions. Our results support the hypothesis that cognitive deficits in HD are not exclusively dominated by frontal\u2010striatal dysfunctions but also involve fronto\u2010temporal and parieto\u2010occipital damage.<\/jats:p>","DOI":"10.1002\/jnr.25174","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:03:37Z","timestamp":1676851417000},"page":"990-999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Structural and metabolic brain correlates of arithmetic word\u2010problem solving in Huntington's disease"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0050-5466","authenticated-orcid":false,"given":"Andrea","family":"Horta\u2010Barba","sequence":"first","affiliation":[{"name":"Movement Disorders Unit, Neurology Department Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Biomedical Research Institute (IIB\u2010Sant Pau)  Barcelona 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