{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:51:14Z","timestamp":1790016674242,"version":"4.0.1"},"reference-count":101,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071883"],"award-info":[{"award-number":["82071883"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Breast cancer (BC) patients who undergo chemotherapy are likely to develop chemotherapy\u2010related cognitive impairment (CRCI). Recent studies of BC patients after chemotherapy have used graph theory to investigate the topological properties of the brain functional connectome. However, little is known about structural morphological networks in BC patients after early neoadjuvant chemotherapy (NAC). Brain morphological network organization in 47 female participants with BC was investigated before and after NAC. Topological properties of brain networks were ascertained based on morphological similarities in regional gray matter using a graph theory approach based on 3D T1\u2010weighted MRI data. Nonparametric permutation testing was used to assess longitudinal\u2010group differences in topological metrics. Compared with BC patients before NAC, BC patients after early NAC showed significantly increased global efficiency (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.048), decreased path length (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.033), and abnormal nodal properties and connectivity, mainly located in the central executive network (CEN). The change in the network efficiency of the right caudate was negatively correlated with the change in the Self\u2010Rating Anxiety Scale score (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a0\u2212.435,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.008), and the change in the nodal degree of the left superior frontal gyrus (dorsolateral part) was positively correlated with the change in the Functional Assessment of Cancer Therapy score (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a0.547,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.002). BC participants showed randomization in global properties and dysconnectivity in the CEN after early NAC. NAC may disrupt the cognitive balance of the brain morphological network in individuals with BC.\n                  <\/jats:p>","DOI":"10.1002\/jnr.25178","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T13:53:43Z","timestamp":1676469223000},"page":"1138-1153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Brain network deficits in breast cancer patients after early neoadjuvant chemotherapy: A longitudinal\n                    <scp>MRI<\/scp>\n                    study"],"prefix":"10.1002","volume":"101","author":[{"given":"Jing","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Radiology Chongqing University Cancer Hospital, School of Medicine, Chongqing University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchun","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Breast Cancer Center 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