{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:11:59Z","timestamp":1772118719375,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T00:00:00Z","timestamp":1679788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["826254"],"award-info":[{"award-number":["826254"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    One\u2010third of boys with X\u2010linked adrenoleukodystrophy (ALD) develop inflammatory demyelinating lesions, typically at the splenium. These lesions share similarities with multiple sclerosis, including cerebral hypoperfusion and links to vitamin D insufficiency. We hypothesized that increasing vitamin D levels would increase cerebral blood flow (CBF) in ALD boys. We conducted an exploratory analysis of vitamin D supplementation and CBF using all available data from participants enrolled in a recent single\u2010arm interventional study of vitamin D supplementation in boys with ALD. We measured whole brain and splenium CBF using arterial spin labeling (ASL) from three study time points (baseline, 6\u2009months, and 12\u00a0months). We used linear generalized estimating equations to evaluate CBF changes between time points and to test for an association between CBF and vitamin D. ASL data were available for 16 participants, aged 2\u201322\u2009years. Mean vitamin D levels increased by 72.7% (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u2009.001) after 6\u2009months and 88.6% (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u2009.01) after 12\u00a0months. Relative to baseline measures, mean CBF of the whole brain (6\u2009months: +2.5%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.57; 12\u00a0months: +6.1%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.18) and splenium (6\u2009months: +1.2%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.80; 12\u00a0months: +7.4%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.058) were not significantly changed. Vitamin D levels were positively correlated with CBF in the splenium (slope\u00a0=\u00a0.59,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u2009.001). In this exploratory analysis, we observed a correlation between vitamin D levels and splenial CBF in ALD boys. We confirm the feasibility of measuring CBF in this brain region and population, but further work is needed to establish a causal role for vitamin D in modulating CBF.\n                  <\/jats:p>","DOI":"10.1002\/jnr.25187","type":"journal-article","created":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T22:34:33Z","timestamp":1679870073000},"page":"1086-1097","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of vitamin D supplementation on cerebral blood flow in male patients with adrenoleukodystrophy"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0210-7739","authenticated-orcid":false,"given":"Moss Y.","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Radiology Stanford University  California Stanford USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7911-6203","authenticated-orcid":false,"given":"Alex","family":"Dahlen","sequence":"additional","affiliation":[{"name":"Quantitative Sciences Unit, Stanford University School of Medicine  California Stanford USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9391-4941","authenticated-orcid":false,"given":"Norma Jimenez","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine  California Stanford USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9163-8741","authenticated-orcid":false,"given":"Michael","family":"Moseley","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University  California Stanford USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0233-9361","authenticated-orcid":false,"given":"Keith","family":"Van\u00a0Haren","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Sciences Stanford University  California Stanford USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5781-8848","authenticated-orcid":false,"given":"Greg","family":"Zaharchuk","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University  California Stanford USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,26]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25197"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20839"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910400308"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1109\/TSP.2008.2005752"},{"key":"e_1_2_13_6_1","first-page":"696","article-title":"Changes in regional cerebral blood flow during brain maturation in children and adolescents","volume":"33","author":"Chiron C.","year":"1992","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17702156"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25938"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-305612"},{"key":"e_1_2_13_10_1","first-page":"1188","article-title":"Consensus recommendations for a standardized brain tumor imaging protocol in clinical trials","volume":"17","author":"Ellingson B. 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