{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:59:18Z","timestamp":1792252758507,"version":"4.4.0"},"reference-count":84,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020607","name":"Hitit \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transcranial direct curent stimulation (tDCS) and trans\u2010spinal direct current stimulation (tsDCS) are promising therapies for pain that can alter the excitability of neuronal activity in cerebral cortex. The aim of the study is to investigate the therapeutic effects of direct current stimulation (DCS) over the spinal cord and cerebral cortex on oxidative stress and neuroinflammation in rats with chronic constriction injury (CCI).\u00a0Male Wistar rats were randomly divided into four experimental groups: Sham, CCI, CCI + tDCS and CCI\u2009+\u2009tsDCS. The neuropathic pain model was induced by using the CCI model. Rats with neuropathy were treated with cathodal tDCS and tsDCS stimulations consisting of 0.5\u2009mA for 30\u2009min a day for 7\u2009days from day 8 onwards. Locomotor activity was measured by open\u2010field test and nociceptive behavior was assessed by hot\u2010plate, tail\u2010flick and Randall\u2013Selitto tests. Following the behavioral experiments, total oxidant capacity (TOC), total antioxidant capacity (TAC) and proinflammatory cytokine levels were evaluated in spinal cord and cerebral cortex tissues. The CCI model induced significant mechanical and thermal hyperalgesia. Nociceptive behaviors in rats with CCI were reversed by DCS treatment. Higher TOC and lower TAC levels were detected in the spinal cord and cerebral cortex tissues of the CCI rats compared to the control. tsDCS treatment amended oxidant\/antioxidant status. Moreover, tsDCS modulated the central levels of Tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), interleukin 1\u2010beta (IL\u20101\u03b2), IL\u20106 and IL\u201018. tsDCS stimulation showed better therapeutic effect on neuropathic pain by regulating oxidant\/antioxidant levels and reducing neuroinflammation. DCS, especially at spinal level, may be a promising therapeutic strategy that can be used alone or in combination with other effective treatments for alleviating neuropathic pain.<\/jats:p>","DOI":"10.1002\/jnr.25204","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T07:50:40Z","timestamp":1686729040000},"page":"1457-1470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Transcranial direct current stimulation alleviates nociceptive behavior in male rats with neuropathic pain by regulating oxidative stress and reducing neuroinflammation"],"prefix":"10.1002","volume":"101","author":[{"given":"Guven","family":"Akcay","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Biophysics Hitit University  \u00c7orum 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