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Considering existing evidences for organic inflammation\u2010triggered neuroplastic changes in the brain serotonergic circuitry, the ambiguous contribution of 5\u2010HT1A receptors to supraspinal control of visceral pain in normal and post\u2010inflammatory conditions can be assumed. In this study performed on male Wistar rats, we used microelectrode recording of the caudal ventrolateral medulla (CVLM) neuron responses to colorectal distension (CRD) and electromyography recording of CRD\u2010evoked visceromotor reactions (VMRs) to evaluate post\u2010colitis changes in the effects of 5\u2010HT1A agonist buspirone on supraspinal visceral nociceptive transmission. In rats recovered from trinitrobenzene sulfonic acid colitis, the CRD\u2010induced CVLM neuronal excitation and VMRs were increased compared with those in healthy animals, revealing post\u2010inflammatory intestinal hypersensitivity. Intravenous buspirone (2 and 4\u2009mg\/kg) under urethane anesthesia dose\u2010dependently suppressed CVLM excitatory neuron responses to noxious CRD in healthy rats, but caused dose\u2010independent increase in the already enhanced nociceptive activation of CVLM neurons in post\u2010colitis animals, losing also its normally occurring faciliatory effect on CRD\u2010evoked inhibitory medullary neurotransmission and suppressive action on hemodynamic reactions to CRD. In line with this, subcutaneous injection of buspirone (2\u2009mg\/kg) in conscious rats, which attenuated CRD\u2010induced VMRs in controls, further increased VMRs in hypersensitive animals. The data obtained indicate a shift from anti\u2010 to pronociceptive contribution of 5\u2010HT1A\u2010dependent mechanisms to supraspinal transmission of visceral nociception in intestinal hypersensitivity conditions, arguing for the disutility of buspirone and possibly other 5\u2010HT1A agonists for relieving post\u2010inflammatory abdominal pain.<\/jats:p>","DOI":"10.1002\/jnr.25222","type":"journal-article","created":{"date-parts":[[2023,6,18]],"date-time":"2023-06-18T12:28:37Z","timestamp":1687091317000},"page":"1555-1571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Opposing effects of\n                    <scp>5\u2010HT1A<\/scp>\n                    receptor agonist buspirone on supraspinal abdominal pain transmission in normal and visceral hypersensitive rats"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6296-4628","authenticated-orcid":false,"given":"Olga A.","family":"Lyubashina","sequence":"first","affiliation":[{"name":"Laboratory of Cortico\u2010Visceral Physiology Pavlov Institute of Physiology of the Russian Academy of Sciences  Saint Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan B.","family":"Sivachenko","sequence":"additional","affiliation":[{"name":"Laboratory of Cortico\u2010Visceral Physiology Pavlov Institute of Physiology of the Russian Academy of Sciences  Saint Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris M.","family":"Sushkevich","sequence":"additional","affiliation":[{"name":"Laboratory of Cortico\u2010Visceral Physiology Pavlov Institute of Physiology of the Russian Academy of Sciences  Saint Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina I.","family":"Busygina","sequence":"additional","affiliation":[{"name":"Laboratory of Cortico\u2010Visceral Physiology Pavlov Institute of Physiology of the Russian Academy of Sciences  Saint Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,18]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","article-title":"Effect of buspirone on inflammation, pain and gastric injury in mice","volume":"6","author":"Abdel Salam O.","year":"2007","journal-title":"The Internet Journal of Pharmacology"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20108993(95)00660\u2010i"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.19576"},{"key":"e_1_2_11_5_1","first-page":"33","volume-title":"Chronic abdominal and visceral pain. 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