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Anxiety disorders are among the most common neuropsychiatric disorders. An increasing number of studies have demonstrated that the CRF family mediates and regulates the development and maintenance of anxiety. Thus, the CRF family is considered to be a potential target for the treatment of anxiety disorders. The prefrontal cortex (PFC) plays a role in the occurrence and development of anxiety, and both CRF and CRF\u2010R1 are widely expressed in the PFC. This paper begins by reviewing CRF\u2010related signaling pathways and their different roles in anxiety and related processes. Then, the role of the CRF system in other neuropsychiatric diseases is reviewed and the potential role of PFC CRF signaling in the regulation of anxiety disorders is discussed. Although other signaling pathways are potentially involved in the process of anxiety, CRF in the PFC primarily modulates anxiety disorders through the activation of corticotropin\u2010releasing factor type1 receptors (CRF\u2010R1)\u00a0and the excitation of the cAMP\/PKA signaling pathway. Moreover, the main signaling pathways of CRF involved in sex differentiation in the PFC appear to be different. In summary, this review suggests that the CRF system in the PFC plays a critical role in the occurrence of anxiety. Thus, CRF signaling is of great significance as a potential target for the treatment of stress\u2010related disorders in the future.<\/jats:p>","DOI":"10.1002\/jnr.25238","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T15:58:48Z","timestamp":1692633528000},"page":"1781-1794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Corticotropin\u2010releasing factor signaling and its potential role in the prefrontal cortex\u2010dependent regulation of anxiety"],"prefix":"10.1002","volume":"101","author":[{"given":"Xin","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Physiology Shantou University Medical College  Shantou China"},{"name":"Department of Transfusion Medicine Xijing Hospital, Fourth Military Medical University  Xi'an 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