{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:53:10Z","timestamp":1787683990845,"version":"build-2784847793"},"reference-count":99,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011947","name":"Abbott Nutrition","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The impact of early life nutrition on myelin development is of interest given that cognitive and behavioral function depends on proper myelination. Evidence shows that myelination can be altered by dietary lipid, but most of these studies have been performed in the context of disease or impairment. Here, we assessed the effects of lipid blends containing various levels of a hydrolyzed fat (HF) system on myelination in healthy piglets. Piglets were sow\u2010reared, fed a control diet, or a diet containing 12%, 25%, or 53% HF consisting of cholesterol, fatty acids, monoglycerides, and phospholipid from lecithin. At postnatal day 28\/29, magnetic resonance imaging (MRI) was performed to assess changes to brain development, followed by brain collection for microscopic analyses of myelin in targeted regions using CLARITY tissue clearing, immunohistochemistry, and electron microscopy techniques. Sow\u2010reared piglets exhibited the highest overall brain white matter volume by MRI. However, a 25% HF diet resulted in the greatest total myelin density in the prefrontal cortex based on 3D modeling analysis of myelinated filaments. Nodal gap length and\n                    <jats:italic>g<\/jats:italic>\n                    \u2010ratio were inversely correlated with percentage of HF in the corpus callosum, as well as in the PFC and internal capsule for\n                    <jats:italic>g<\/jats:italic>\n                    \u2010ratio, indicating that a 53% HF diet resulted in the thickest myelin per axon and a 0% HF control diet the thinnest in specific brain regions. These findings indicate that HF promoted myelination in the neonatal piglet in a region\u2010 and concentration\u2010dependent manner.\n                  <\/jats:p>","DOI":"10.1002\/jnr.25243","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T06:12:28Z","timestamp":1695363148000},"page":"1864-1883","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A hydrolyzed lipid blend diet promotes myelination in neonatal piglets in a region and concentration\u2010dependent manner"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9247-223X","authenticated-orcid":false,"given":"Allison Y.","family":"Louie","sequence":"first","affiliation":[{"name":"Neuroscience Program University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie A.","family":"Rund","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin A.","family":"Komiyama\u2010Kasai","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsie E.","family":"Weisenberger","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla L.","family":"Stanke","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"},{"name":"Department of Psychology University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Leyshon","sequence":"additional","affiliation":[{"name":"Abbott Nutrition  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Kuchan","sequence":"additional","affiliation":[{"name":"Abbott Nutrition  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapas","family":"Das","sequence":"additional","affiliation":[{"name":"Abbott Nutrition  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Steelman","sequence":"additional","affiliation":[{"name":"Neuroscience Program University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"},{"name":"Department of Animal Sciences University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"},{"name":"Division of Nutritional Sciences University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"},{"name":"Carl R. 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