{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:12:50Z","timestamp":1772118770948,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003655","name":"National Institute of Food and Drug Safety Evaluation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>3\u2010Fluoroethamphetamine (3\u2010FEA) belongs to the amphetamine class of stimulant drugs and functions as a releasing agent for the monoamine neurotransmitters norepinephrine, dopamine, and serotonin. 3\u2010FEA acts on the central nervous system and elicits physical and mental side effects, such as euphoria, increased heart rate, and excitement. However, little is known about the withdrawal symptoms and behavioral changes induced by 3\u2010FEA administration. This study aimed to evaluate the short\u2010term consequences of 3\u2010FEA administration (twice a day, 7\u2009days, i.p.; 1 and 10\u2009mg\/kg) in C57BL\/6J mice (male, 7\u2009weeks old) at three behavioral levels following 1\u20134\u2009days of withdrawal. The evaluation included (1) withdrawal score, (2) hyperactivity (open field [OF], elevated plus maze [EPM], and cliff avoidance [CA] test), and (3) depression\u2010like behavior (forced\u2010swim test). In the withdrawal score test, withdrawal behavior increased in all 3\u2010FEA groups at 16 and 40\u2009h after withdrawal. In the OF, EPM, and CA tests, the 3\u2010FEA administration group showed significant changes in terms of hyperactivity. In addition, in the forced\u2010swim test, both the 1\u2009mg\/kg and 10\u2009mg\/kg 3\u2010FEA groups showed increased immobility time. These findings indicate that 3\u2010FEA administration may lead to physical dependence, demonstrated by the withdrawal score increase and significant changes in hyperactivity and depression\u2010like behavior following repeated administration and drug cessation. In conclusion, this study reveals the adverse consequences of 3\u2010FEA administration and highlights the need for awareness raising and regulatory action to control the use of this new psychoactive substance.<\/jats:p>","DOI":"10.1002\/jnr.25251","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T01:15:47Z","timestamp":1697073347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Withdrawal from\n                    <scp>3\u2010Fluoroethamphetamine<\/scp>\n                    induces hyperactivity and depression\u2010like behaviors in male mice"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8960-8351","authenticated-orcid":false,"given":"Cheolmin","family":"Jo","sequence":"first","affiliation":[{"name":"Pharmacological Research Division, Toxicological Evaluation and Research Department National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety  Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyejin","family":"Joo","sequence":"additional","affiliation":[{"name":"Pharmacological Research Division, Toxicological Evaluation and Research Department National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety  Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na Young","family":"Lim","sequence":"additional","affiliation":[{"name":"Pharmacological Research Division, Toxicological Evaluation and Research Department National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety  Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su\u2010Jeong","family":"Park","sequence":"additional","affiliation":[{"name":"Pharmacological Research Division, Toxicological Evaluation and Research Department National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety  Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Ok","family":"Choi","sequence":"additional","affiliation":[{"name":"Pharmacological Research Division, Toxicological Evaluation and Research Department National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety  Cheongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.05.003"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.5717\/jenb.2014.18.4.379"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01730-4"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e32833c7cc8"},{"key":"e_1_2_12_6_1","unstructured":"EMCDDA. 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