{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:53:54Z","timestamp":1784782434415,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["(2021QN020;2023KFZX007)"],"award-info":[{"award-number":["(2021QN020;2023KFZX007)"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The basolateral amygdala (BLA) appears to serve an important function in the pathophysiology of depression. Depressive symptoms, such as anhedonia are largely caused by dysfunction in the brain's reward system, in which the ventral pallidum (VP) participates in by controlling dopamine release. However, the role of the BLA\u2010VP pathway in the development of depression remains poorly understood. To investigate this pathway, we employed the Chronic Unpredictable Mild Stress (CUMS) mouse model, in which we injected retroAAV expressing GFP\u2010Cre into the VP and AAV expressing hM4Di\u2010mCherry into the BLA. We then used CNO to activate the Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) for all behavioral tests. The CUMS procedure resulted in significant depression symptoms such as decreased sucrose preference, limited weight gain, decreased immobile latency, and increased immobile time in the forced swim and tail suspension tests. Inhibition of the BLA\u2010VP glutamatergic projections reversed these depression\u2010like behaviors. We found that suppressing the BLA\u2010VP circuitry had beneficial effects on CUMS\u2010induced depression\u2010like behaviors such as anorexia, anhedonia, and despair. Specifically, upon suppression of glutamatergic projections in the BLA\u2010VP circuitry, these depression\u2010like behaviors were significantly alleviated, which highlights the vital role of this circuitry in the development of depression. Furthermore, the beneficial effects of suppressing this circuitry seem to be associated with the brain's reward system, warranting further investigation.<\/jats:p>","DOI":"10.1002\/jnr.25258","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T06:29:16Z","timestamp":1696919356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The role of amygdala\u2010ventral pallidum pathway in depression\u2010like behaviors in male mice"],"prefix":"10.1002","volume":"102","author":[{"given":"Hao","family":"Guo","sequence":"first","affiliation":[{"name":"School of Sports Medicine and Rehabilitation Beijing Sport University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintao","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Automation and information Engineering Xi'an University of Technology  Xi'an 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