{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T06:11:31Z","timestamp":1772345491153,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101492"],"award-info":[{"award-number":["82101492"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The olfactory working memory capacity (OWMC) paradigm is able to detect cognitive deficits in 5XFAD mice (an animal model of Alzheimer's disease [TG]) as early as 3\u2009months of age, while other behavioral paradigms detect cognitive deficits only at 4\u20135\u2009months of age. Therefore, we aimed to demonstrate that the OWMC paradigm is more sensitive and consistent in the early detection of declines in cognitive function than other commonly used behavioral paradigms. The prefrontal cortex (PFC), retrosplenial cortex (RSC), subiculum (SUB), and amygdala (AMY) of 5XFAD mice were harvested and subjected to immunostaining to detect the expression of \u03b2\u2010amyloid (A\u03b2). Additionally, we compared the performance of 3\u2010month\u2010old male 5XFAD mice on common behavioral paradigms for assessing cognitive function (i.e., the open field [OF] test, novel object recognition [NOR] test, novel object location [NOL] test, Y\u2010maze, and Morris water maze [MWM]) with that on the OWMC task. In the testing phase of the OWMC task, we varied the delay periods to evaluate the working memory capacity (WMC) of wild\u2010type (WT) mice. Significant amyloid plaque deposition was observed in the PFC, RSC, SUB, and AMY of 3\u2010month\u2010old male 5XFAD mice. However, aside from the OWMC task, the other behavioral tests failed to detect cognitive deficits in 5XFAD mice. Additionally, to demonstrate the efficacy of the OWMC task in assessing WMC, we varied the retention delay periods; we found that the WMC of WT mice decreased with longer delay periods. The OWMC task is a sensitive and robust behavioral assay for detecting changes in cognitive function.<\/jats:p>","DOI":"10.1002\/jnr.25265","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T08:17:45Z","timestamp":1699604265000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The olfactory working memory capacity paradigm: A more sensitive and robust method of assessing cognitive function in male\n                    <scp>5XFAD<\/scp>\n                    mice"],"prefix":"10.1002","volume":"102","author":[{"given":"Li\u2010Xin","family":"Jiang","sequence":"first","affiliation":[{"name":"Peking University Institute of Mental Health (Sixth Hospital)  Beijing China"},{"name":"National Clinical Research Center for Mental Disorders &amp; NHC Key Laboratory of Mental Health (Peking University)  Beijing China"},{"name":"Beijing Municipal Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geng\u2010Di","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Addiction Medicine Shenzhen Clinical Research Center for Mental Disorders, Shenzhen Mental Health Center, Shenzhen Kangning Hospital  Shenzhen China"},{"name":"Affiliated Mental Health Center Southern University of Science and Technology  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua\u2010Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University Institute of Mental Health (Sixth Hospital)  Beijing China"},{"name":"National Clinical Research Center for Mental Disorders &amp; NHC Key Laboratory of Mental Health (Peking University)  Beijing China"},{"name":"Beijing Municipal Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Beijing Key Laboratory of Neural Regeneration and Repair, Advanced Innovation Center for Human Brain Protection Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Yu","sequence":"additional","affiliation":[{"name":"Peking University Institute of Mental Health (Sixth Hospital)  Beijing China"},{"name":"National Clinical Research Center for Mental Disorders &amp; NHC Key Laboratory of Mental Health (Peking University)  Beijing China"},{"name":"Beijing Municipal Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.03.001"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-200210000-00001"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963721412459513"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202753"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089454"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(07)00020-9"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.120"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-010814-015031"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012974"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.3.noc60123"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007901"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016564"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb09279.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9280.2005.01612.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30028-0"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.1424"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-01120-w"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.05.027"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-020-05452-9"},{"key":"e_1_2_11_22_1","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2703","article-title":"The protocol for assessing olfactory working memory capacity in mice","volume":"00","author":"Jiang L. 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