{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:19:10Z","timestamp":1782937150752,"version":"3.54.5"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007957","name":"Chongqing Municipal Education Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In this study, we explored the application of diffusion kurtosis imaging (DKI) technology in the brains of children with attention\u2010deficit\/hyperactivity disorder (ADHD). Seventy\u2010two children with ADHD and 79 age\u2010 and sex\u2010matched healthy controls were included in the study. All children were examined by means of 3D T1\u2010weighted image, DKI, and conventional sequence scanning. The volume and DKI parameters of each brain region were obtained by software postprocessing (GE ADW 4.6 workstation) and compared between the two groups of children to determine the imaging characteristics of children with ADHD. The result showed the total brain volume was lower in children with ADHD than in healthy children (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05). The gray and white matter volumes in the frontal lobe, temporal lobe, hippocampus, caudate nucleus, putamen, globus pallidus, and other brain regions were lower in children with ADHD than in healthy children (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05). The axial kurtosis (Ka), mean kurtosis (MK), fractional anisotropy (FA), and radial kurtosis(Kr) values in the frontal lobe, temporal lobe, and caudate nucleus of children with ADHD were lower than those of healthy children, while the mean diffusivity(MD) and fractional anisotropy of kurtosis (FAK) values were higher than those of healthy children (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05). Additionally, the Ka, MK, FA, and Kr values in the frontal lobe, caudate nucleus, and temporal lobe could be used to distinguish children with ADHD (AUC\u2009&gt;\u2009.05,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05). In conclusion, DKI showed abnormal gray matter and white matter development in some brain regions of children with ADHD.\n                  <\/jats:p>","DOI":"10.1002\/jnr.25284","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T16:22:59Z","timestamp":1702398179000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Diffusion kurtosis imaging reveals abnormal gray matter and white matter development in some brain regions of children with attention\u2010deficit\/hyperactivity disorder"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9207-7798","authenticated-orcid":false,"given":"Shilong","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Radiology Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7432-1048","authenticated-orcid":false,"given":"Xianfan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Nie","sequence":"additional","affiliation":[{"name":"GE Healthcare MR Research China  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wushuang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4389-7973","authenticated-orcid":false,"given":"Ling","family":"He","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9203-6486","authenticated-orcid":false,"given":"Mei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neonatal Diagnosis and Treatment Center Children's Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22317"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.14050"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166\u20102236(89)90074\u2010x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27019"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12778"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copsyc.2019.09.006"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u2010444\u201064189\u20102.00004\u20104"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910\u2010001\u20100060\u20104"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2020.01.035"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25718"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975\u2010020\u201000868\u2010z"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201021428\u20104"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2020.08.014"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00192"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010021\u201001301\u20101"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.962911"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2022.111568"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.3162"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/NP.2003.107"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22397"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.11.221"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2020.590815"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.803066"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1518"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20508"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.112382"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/1087054719855683"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260295"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-02130-6"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00062\u2010015\u20100469\u20109"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2021.109900"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010021\u201010949\u20100"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2017.06.006"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224343"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcv2.12152"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.13132"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2023.101222"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010023\u201002173\u20101"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000669"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2018.01.009"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u201012\u2010804281\u20106.00019\u20107"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24985"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.02.011"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.504"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.15485"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.6.FOCUS16192"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.13696"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology11091320"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2016.06.008"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-032814-112800"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682\u2010019\u201000108\u20105"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26854"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2021.110477"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.710133"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.25284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T06:04:57Z","timestamp":1712729097000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.25284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,12]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/jnr.25284"],"URL":"https:\/\/doi.org\/10.1002\/jnr.25284","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JNR.25284\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25284\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25284\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25284\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25284\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25284\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25284\/v4\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25284\/v6\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25284\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25284\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25284\/v5\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25284\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25284\/v5\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25284\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25284\/v4\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25284\/v6\/decision1","asserted-by":"object"}]},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,12]]},"assertion":[{"value":"2023-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e25284"}}