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In this cross\u2010sectional study, structural neuroimaging was performed to measure cortical thickness (CT) in tricenarian adults with cocaine use disorder (CUD,\n                    <jats:italic>n<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    \u2009=\u200930) and their age\u2010paired controls (YC,\n                    <jats:italic>n<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    \u2009=\u200930), and compare it with octogenarian elder controls (EC,\n                    <jats:italic>n<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    \u2009=\u200920). We found that CT in the right fusiform gyrus was similar between CUD and EC, thinner than the expected values of YC. We also found that regarding CT of the right inferior temporal gyrus, right inferior parietal cortex, and left superior parietal cortex, the CUD group exhibited parameters that fell in between EC and YC groups. Finally, CT of the right pars triangularis bordering with orbitofrontal gyrus, right superior temporal gyrus, and right precentral gyrus were reduced in CUD when contrasted with YC, but those areas were unrelated to CT of EC. Despite the 50\u2010year age gap between our age groups, CT of tricenarian cocaine users assembles features of an octogenarian brain, reinforcing the accelerated aging hypothesis in CUD.\n                  <\/jats:p>","DOI":"10.1002\/jnr.25287","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T06:26:24Z","timestamp":1703744784000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The cortical thickness of tricenarian cocaine users assembles features of an octogenarian brain"],"prefix":"10.1002","volume":"102","author":[{"given":"Leonardo Melo","family":"Rothmann","sequence":"first","affiliation":[{"name":"Translational Neuropsychiatry Unit, Department of Clinical Medicine, Graduate School of Health Aarhus University  Aarhus Denmark"},{"name":"Brain Institute (BraIns) Pontifical Catholic University of Rio Grande do Sul  Porto Alegre Brazil"},{"name":"Graduate Program in Medicine and Health Sciences Pontifical Catholic University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucca Pizzato","family":"Tondo","sequence":"additional","affiliation":[{"name":"Brain Institute (BraIns) Pontifical Catholic University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wyllians Vendramini","family":"Borelli","sequence":"additional","affiliation":[{"name":"Brain Institute (BraIns) Pontifical Catholic University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalia Bianchini","family":"Esper","sequence":"additional","affiliation":[{"name":"Center for the Developing Brain Child Mind Institute  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Tavares","family":"Portolan","sequence":"additional","affiliation":[{"name":"Brain Institute (BraIns) Pontifical Catholic University of Rio Grande do Sul  Porto Alegre Brazil"},{"name":"School of Medicine Pontifical Catholic University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Rosa","family":"Franco","sequence":"additional","affiliation":[{"name":"Center for the Developing Brain Child Mind Institute  New York New York USA"},{"name":"Nathan S. 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