{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:56Z","timestamp":1786978016076,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Environment enrichment (EE) is a well\u2010known eustress model showing beneficial effects in different psychiatric diseases, but its positive properties in panic disorders are not yet established. The confrontation between prey and predator in complex arenas has been validated as a putative panic attack model. The principal aim of this work was to investigate the role of the EE on panic\u2010like defensive responses elicited by mice threatened by venomous snakes. After 6\u2009weeks of exposure either to an enriched or standard environments, 36 male mice were habituated in a complex polygonal arena for snakes containing an artificial burrow and elevated platforms for escape. The animals were confronted by\n                    <jats:italic>Bothrops jararaca<\/jats:italic>\n                    for 5 min, and the following antipredatory responses were recorded: defensive attention, stretched attend posture, flat back approach, prey versus predator interaction, oriented escape behavior, time spent in a safe place, and number of crossings. Mice threatened by snakes displayed several antipredatory reactions as compared to the exploratory behavior of those animals submitted to a nonthreatening situation (toy snake) in the same environment. Notably, EE causes anxiolytic\u2010 and panicolytic\u2010like effects significantly decreasing the defensive attention and time spent in safe places and significantly increasing both prey versus predator interaction and exploratory behavior. In conclusion, our data demonstrate that EE can alter the processing of fear modulation regarding both anxiety\u2010 and panic\u2010like responses in a dangerous condition, significantly modifying the decision\u2010making defensive strategy.\n                  <\/jats:p>","DOI":"10.1002\/jnr.25300","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T02:17:44Z","timestamp":1707272264000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Panicolytic\u2010like effects of environment enrichment on male mice threatened by\n                    <i>Bothrops jararaca<\/i>\n                    lancehead pit vipers"],"prefix":"10.1002","volume":"102","author":[{"given":"Bruno Mangili","family":"de Paula\u00a0Rodrigues","sequence":"first","affiliation":[{"name":"Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology Ribeir\u00e3o Preto Medical School of the University of 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