{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:22:16Z","timestamp":1778750536972,"version":"3.51.4"},"reference-count":82,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071905"],"award-info":[{"award-number":["82071905"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901726"],"award-info":[{"award-number":["81901726"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive decline. Sex differences in the progression of AD exist, but the neural mechanisms are not well understood. The purpose of the current study was to explore sex differences in brain functional connectivity (FC) at different stages of AD and their predictive ability on Montreal Cognitive Assessment (MoCA) scores using connectome\u2010based predictive modeling (CPM). Resting\u2010state functional magnetic resonance imaging was collected from 81 AD patients (44 females), 78 amnestic mild cognitive impairment patients (44 females), and 92 healthy controls (50 females). The FC analysis was conducted and the interaction effect between sex and group was investigated using two\u2010factor variance analysis. The CPM was used to predict MoCA scores. There were sex\u2010by\u2010group interaction effects on FC between the left dorsolateral superior frontal gyrus and left middle temporal gyrus, left precuneus and right calcarine fissure surrounding cortex, left precuneus and left middle occipital gyrus, left middle temporal gyrus and left precentral gyrus, and between the left middle temporal gyrus and right cuneus. In the CPM, the positive network predictive model significantly predicted MoCA scores in both males and females. There were significant sex\u2010by\u2010group interaction effects on FC between the left precuneus and left middle occipital gyrus, and between the left middle temporal gyrus and right cuneus could predict MoCA scores in female patients. Our results suggest that there are sex differences in FC at different stages of AD. The sex\u2010specific FC can further predict MoCA scores at individual level.<\/jats:p>","DOI":"10.1002\/jnr.25307","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T02:29:55Z","timestamp":1709692195000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sex differences in functional connectivity and the predictive role of the connectome\u2010based predictive model in Alzheimer's disease"],"prefix":"10.1002","volume":"102","author":[{"given":"Yuqing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanqiu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziwen","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7343-6241","authenticated-orcid":false,"given":"Yongqiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9109-7385","authenticated-orcid":false,"given":"Xiaoshu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3874-05.2006"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-132516"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66665-2"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24135"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhl078"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.007"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210406"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2014.00074"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.011"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2177-05.2005"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)71969-5"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/23279095.2014.927767"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1948.11.1.31"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn755"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.126"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1194144"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70178-3"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.30.051606.094328"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-vision-091718-014809"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-122002"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550160069041"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4135"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012372560-8\/50002-4"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1993.4"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.10.047"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06624-y"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh400"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12176"},{"key":"e_1_2_11_32_1","first-page":"1586","article-title":"Executive dysfunction and the prefrontal cortex","volume":"27","author":"Jones D. T.","year":"2021","journal-title":"Continuum"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.02.066"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13430"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2022.12.001"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-018-9975-0"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00250"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.639529"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu316"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1800381"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2015.07.001"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00094"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180183"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5472.1835"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0193(1998)6:5\/6<383::AID-HBM10>3.0.CO;2-Z"},{"issue":"1","key":"e_1_2_11_46_1","first-page":"S163","article-title":"Brain structural and functional connectivity and the progression of neuropathology in Alzheimer's disease","volume":"33","author":"Matthews P. M.","year":"2013","journal-title":"Journal of Alzheimer's Disease"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)00067-3"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-014-0744-6"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12940"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-019-0917-z"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.10.099"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.676"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02965"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(08)70493-3"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4179"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5587-06.2007"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.11.028"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.178"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.07.038"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708803104"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800005105"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.07.219"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200087"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116756"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.01.080"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12266"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001788"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2614"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90355.2008"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm105"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20935274"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22234"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4478"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01333"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00350"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-021-03830-w"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2015.03.002"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.04.012"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.25307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T05:15:58Z","timestamp":1714367758000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.25307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":82,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/jnr.25307"],"URL":"https:\/\/doi.org\/10.1002\/jnr.25307","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JNR.25307\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25307\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25307\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25307\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25307\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25307\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25307\/v4\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25307\/v4\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25307\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25307\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25307\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25307\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2023-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e25307"}}