{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:53:55Z","timestamp":1787313235829,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871046"],"award-info":[{"award-number":["81871046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Post\u2010traumatic stress disorder (PTSD), a psychological condition triggered by exposure to extreme or chronic stressful events, exhibits a sex bias in incidence and clinical manifestations. Emerging research implicates the gut microbiome in the pathogenesis of PTSD and its roles in stress susceptibility. However, it is unclear whether differential gut microbiota contribute to PTSD susceptibility in male and female rats. Here, we utilized the single prolonged stress animal model and employed unsupervised machine learning to classify stressed animals into stress\u2010susceptible subgroups and stress\u2010resilient subgroups. Subsequently, using 16S V3\u2010V4 rDNA sequencing, we investigated the differential gut microbiota alterations between susceptible and resilient individuals in male and female rats. Our findings revealed distinct changes in gut microbiota composition between the sexes at different taxonomic levels. Furthermore, the abundance of\n                    <jats:italic>Parabacteroides<\/jats:italic>\n                    was lower in rats that underwent SPS modeling compared to the control group. In addition, the abundance of\n                    <jats:italic>Tenericutes<\/jats:italic>\n                    in the stress\u2010susceptible subgroup was higher than that in the control group and stress\u2010resilient subgroup, suggesting that\n                    <jats:italic>Tenericutes<\/jats:italic>\n                    may be able to characterize stress susceptibility. What is particularly interesting here is that\n                    <jats:italic>Cyanobacteria<\/jats:italic>\n                    may be particularly associated with anti\u2010anxiety effects in male rats. This study underscores sex\u2010specific variations in gut microbiota composition in response to stress and sex differences should be taken into account when using macrobiotics for neuropsychiatric treatment, highlighting potential targets for PTSD therapeutic interventions.\n                  <\/jats:p>","DOI":"10.1002\/jnr.25315","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T01:46:50Z","timestamp":1709603210000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The gut microbiome modulates the susceptibility to traumatic stress in a sex\u2010dependent manner"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8547-6044","authenticated-orcid":false,"given":"Dan","family":"Shen","sequence":"first","affiliation":[{"name":"Henan Key Laboratory of Medical Tissue Regeneration Xinxiang Medical University  Xinxiang 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