{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:12:32Z","timestamp":1772118752137,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003715","name":"Korea Research Institute of Bioscience and Biotechnology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003715","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003706","name":"Korea Research Institute of Standards and Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003706","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Aberrant neovascularization is the most common feature in retinopathy of prematurity (ROP), which leads to the retinal detachment and visual defects in neonates with a low gestational age eventually. Understanding the regulation of inappropriate angiogenic signaling benefits individuals at\u2010risk. Recently, neural activity originating from the specific neural activity has been considered to contribute to retinal angiogenesis. Here, we explored the impact of cone cell dysfunction on oxygen\u2010induced retinopathy (OIR), a mouse model commonly employed to understand retinal diseases associated with abnormal blood vessel growth, using the\n                    <jats:italic>Gnat2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>cpfl3<\/jats:italic>\n                    <\/jats:sup>\n                    (cone photoreceptor function loss\u20103) strain of mice (regardless of the sex), which is known for its inherent cone cell dysfunction. We found that the retinal avascular area, hypoxic area, and neovascular area were significantly attenuated in\n                    <jats:italic>Gnat2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>cpfl3<\/jats:italic>\n                    <\/jats:sup>\n                    OIR mice compared to those in C57BL\/6 OIR mice. Moreover, the HIF\u20101\u03b1\/VEGF axis was also reduced in\n                    <jats:italic>Gnat2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>cpfl3<\/jats:italic>\n                    <\/jats:sup>\n                    OIR mice. Collectively, our results indicated that cone cell dysfunction, as observed in\n                    <jats:italic>Gnat2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>cpfl3<\/jats:italic>\n                    <\/jats:sup>\n                    OIR mice, leads to attenuated retinal neovascularization. This finding suggests that retinal neural activity may precede and potentially influence the onset of pathological neovascularization.\n                  <\/jats:p>","DOI":"10.1002\/jnr.25316","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T08:50:33Z","timestamp":1709110233000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cone cell dysfunction attenuates retinal neovascularization in oxygen\u2010induced retinopathy mouse model"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8312-2395","authenticated-orcid":false,"given":"Jun","family":"Wu","sequence":"first","affiliation":[{"name":"Fight Against Angiogenesis\u2010Related Blindness (FARB) Laboratory, Biomedical Research Institute Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Department of Biomedical Sciences Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Hyun","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Fruttiger","sequence":"additional","affiliation":[{"name":"UCL Institute of Ophthalmology, University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2957-1766","authenticated-orcid":false,"given":"Jeong Hun","family":"Kim","sequence":"additional","affiliation":[{"name":"Fight Against Angiogenesis\u2010Related Blindness (FARB) Laboratory, Biomedical Research Institute Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Department of Biomedical Sciences Seoul National University College of Medicine  Seoul Republic of Korea"},{"name":"Department of Ophthalmology Seoul National University College of Medicine  Seoul Republic of Korea"},{"name":"Global Excellence Center for Gene &amp; Cell Therapy (GEC\u2010GCT) Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Institute of Reproductive Medicine and Population Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.21769\/bioprotoc.1254"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2010.04.008"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096494"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901880204"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05\u20101468"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.4.26"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.187"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05\u20101638"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1311193110"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109394(14)73920\u20100"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(13)60178\u20106"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.10.106"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/eb.S94447"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.07.034"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.181329198"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2018.12.006"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700336R"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2021.100879"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12235"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3791\/53030"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.09.004"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.09590"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201004\u2010396846"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci42142"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2013.12.020"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.11.001"},{"issue":"1","key":"e_1_2_11_28_1","first-page":"101","article-title":"Oxygen\u2010induced retinopathy in the mouse","volume":"35","author":"Smith L. 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