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Some symptom phenotypes, for example, covert repugnant thoughts, are likely less sensitive to sensory stimuli compared to symptoms with an extrinsic focus, that is, symptoms related to contamination, safety, and \u201cjust\u2010right\u2010perceptions.\u201d Toward an improved understanding of the neurocognitive underpinnings of obsessive\u2010compulsive psychobiology, work in naturalistic animal model systems is useful. Here, we explored the impact of visual feedback and limbic processes on 24 normal (NNB) and large (LNB) nesting deer mice, respectively (as far as possible, equally distributed between sexes). Briefly, after behavioral classification into either the NNB or LNB cohorts, mice of each cohort were separated into two groups each and assessed for nesting expression under either standard light conditions or conditions of complete visual deprivation (VD). Nesting outcomes were assessed in terms of size and neatness. After nesting assessment completion, mice were euthanized, and samples of frontal\u2010cortical and hippocampal tissues were collected to determine serotonin and noradrenaline concentrations. Our results show that LNB, as opposed to NNB, represents an inflexible and excessive behavioral phenotype that is not dependent on visually guided action\u2010outcome processing, and that it associates with increased frontal\u2010cortical and hippocampal noradrenaline concentrations, irrespective of lighting condition. Collectively, the current results are informing of the neurocognitive underpinnings of nesting behavior. It also provides a valuable foundation for continued investigations into the noradrenergic mechanisms that may influence the development and promulgation of excessive, rigid, and inflexible behaviors.<\/jats:p>","DOI":"10.1002\/jnr.25320","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T03:09:43Z","timestamp":1710990583000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Large nesting expression in deer mice remains stable under conditions of visual deprivation despite heightened limbic involvement: Perspectives on compulsive\u2010like behavior"],"prefix":"10.1002","volume":"102","author":[{"given":"Harry","family":"Marx","sequence":"first","affiliation":[{"name":"Center of Excellence for Pharmaceutical Sciences North\u2010West University  Potchefstroom South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Krahe","sequence":"additional","affiliation":[{"name":"Department of Psychology Pontifical Catholic University of Rio de Janeiro (PUC\u2010Rio)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3440-4869","authenticated-orcid":false,"given":"De Wet","family":"Wolmarans","sequence":"additional","affiliation":[{"name":"Center of Excellence for Pharmaceutical Sciences North\u2010West University  Potchefstroom South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocrd.2015.01.002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.04.025"},{"key":"e_1_2_11_4_1","volume-title":"Diagnostic and statistical manual of mental disorders (DSM\u20105\u00ae)","author":"APA","year":"2013"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.01.027"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20723"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1258\/002367706777611488"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","unstructured":"Bednarek L. 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