{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T20:55:56Z","timestamp":1792356956765,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Patients with symptomatic intracranial arterial stenosis (sICAS) suffer embarrassed hemodynamic status and acute ischemic stroke (AIS) recurrence. We aimed to assess the efficacy of remote ischemic conditioning (RIC) on improving this status by evaluating cerebral blood flow (CBF) and cerebral glucose metabolism (CGM) via PET\/CT. Adult patients with unilateral sICAS in middle cerebral artery and\/or intracranial segment of internal carotid artery\u2010related AIS or transient ischemic attack within 6\u2009months prior to randomization were enrolled. Individuals who received intravenous thrombolysis or endovascular treatment, or sICAS caused by cardiac embolism, small vessel occlusion, or other determined causes were excluded. Twenty\u2010three eligible patients were randomly assigned to standard medical treatment (SMT) (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910) or RIC group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200913). The RIC protocol consisted of 5\u2009cycles, each for 5\u2010min bilateral upper limb ischemia and 5\u2010min reperfusion period, twice a day, with a total duration of 3\u2009months. Ten healthy volunteers were enrolled as healthy control group. We tested CBF and CGM at the rest stage and the methazolamide\u2010induced stress stage. All patients received PET\/CT at baseline and three\u2010month followup. Both CBF and CGM in ipsilateral hemisphere of sICAS patients were significantly decreased at the rest stage and the stress stage (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05), which were improved by three\u2010month RIC (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05). The lesions decreased notably in RIC group compared to SMT group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05). RIC ameliorated the hemodynamic status and glucose metabolism in regions at high risk of infarction, which might improve the resistance capacity towards ischemic load in sICAS patients.\n                  <\/jats:p>","DOI":"10.1002\/jnr.25324","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T03:03:53Z","timestamp":1711076633000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Remote ischemic conditioning improves cerebral hemodynamics in symptomatic intracranial atherosclerosis: A\n                    <scp>PET<\/scp>\n                    \/\n                    <scp>CT<\/scp>\n                    \u2010guided randomized controlled study"],"prefix":"10.1002","volume":"102","author":[{"given":"Hong","family":"An","sequence":"first","affiliation":[{"name":"Department of Neurology, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"},{"name":"Cerebrovascular and Neuroscience Research Institute, Xuanwu Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongrui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanjie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlei","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longfei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University  Beijing 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