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This study investigated the effects of CBD treatment on brain glucose metabolism, in a CUD animal model, using [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG positron emission tomography (PET). Male C57Bl\/6 mice were injected with cocaine (20\u2009mg\/kg, i.p.) every other day for 9\u2009days, followed by 8\u2009days of CBD administration (30\u2009mg\/kg, i.p.). After 48\u2009h, animals were challenged with cocaine. Control animals received saline\/vehicle. [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG PET was performed at four time points: baseline, last day of sensitization, last day of withdrawal\/CBD treatment, and challenge. Subsequently, the animals were euthanized and immunohistochemistry was performed on the hippocampus and amygdala to assess the CB1 receptors, neuronal nuclear protein, microglia (Iba1), and astrocytes (GFAP). Results showed that cocaine administration increased [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG uptake following sensitization. CBD treatment also increased [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG uptake in both saline and cocaine groups. However, animals that were sensitized and challenged with cocaine, and those receiving only an acute cocaine injection during the challenge phase, did not exhibit increased [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG uptake when treated with CBD. Furthermore, CBD induced modifications in the integrated density of NeuN, Iba, GFAP, and CB1R in the hippocampus and amygdala. This is the first study addressing the impact of CBD on brain glucose metabolism in a preclinical model of CUD using PET. Our findings suggest that CBD disrupts cocaine\u2010induced changes in brain energy consumption and activity, which might be correlated with alterations in neuronal and glial function.\n                  <\/jats:p>","DOI":"10.1002\/jnr.25327","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T09:29:10Z","timestamp":1712568550000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of cannabidiol on brain glucose metabolism of\n                    <scp>C57Bl<\/scp>\n                    \/6 male mice previously exposed to cocaine"],"prefix":"10.1002","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6526-2915","authenticated-orcid":false,"given":"Lidia Emmanuela Wiazowski","family":"Spelta","sequence":"first","affiliation":[{"name":"Laboratory of Neurotoxicology, Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Laboratory of Nuclear Medicine, Department of Radiology and Oncology, Faculty of Medicine University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6096-3341","authenticated-orcid":false,"given":"Caroline Cristiano","family":"Real","sequence":"additional","affiliation":[{"name":"Laboratory of Nuclear Medicine, Department of Radiology and Oncology, Faculty of Medicine University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Department of Clinical Medicine, Nuclear Medicine and PET Centre Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1092-523X","authenticated-orcid":false,"given":"Vitor","family":"Bruno","sequence":"additional","affiliation":[{"name":"Laboratory of Neurotoxicology, Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0956-2790","authenticated-orcid":false,"given":"Carlos Alberto","family":"Buchpiguel","sequence":"additional","affiliation":[{"name":"Laboratory of Nuclear Medicine, Department of Radiology and Oncology, Faculty of Medicine University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7080-3955","authenticated-orcid":false,"given":"Raphael Caio Tamborelli","family":"Garcia","sequence":"additional","affiliation":[{"name":"Institute of Environmental, Chemical and Pharmaceutical Sciences Federal University of S\u00e3o Paulo  Diadema Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7065-7484","authenticated-orcid":false,"given":"Larissa Helena","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Food and Drugs, School of Pharmaceutical Sciences Federal University of Alfenas  Alfenas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1766-2786","authenticated-orcid":false,"given":"Daniele","family":"de Paula\u00a0Faria","sequence":"additional","affiliation":[{"name":"Laboratory of Nuclear Medicine, Department of Radiology and Oncology, Faculty of Medicine University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0076-5017","authenticated-orcid":false,"given":"Tania","family":"Marcourakis","sequence":"additional","affiliation":[{"name":"Laboratory of Neurotoxicology, Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2021.113546"},{"key":"e_1_2_13_3_1","volume-title":"III Levantamento Nacional sobre o uso de drogas pela popula\u00e7\u00e3o brasileira","author":"Bastos F. 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