{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:07:26Z","timestamp":1793808446136,"version":"4.6.1"},"reference-count":82,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971071"],"award-info":[{"award-number":["81971071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Increasing neuroimaging studies have attempted to identify biomarkers of Huntington's disease (HD) progression. Here, we conducted voxel\u2010based meta\u2010analyses of voxel\u2010based morphometry (VBM) studies on HD to investigate the evolution of gray matter volume (GMV) alterations and explore the effects of genetic and clinical features on GMV changes. A systematic review was performed to identify the relevant studies. Meta\u2010analyses of whole\u2010brain VBM studies were performed to assess the regional GMV changes in all HD mutation carriers, in presymptomatic HD (pre\u2010HD), and in symptomatic HD (sym\u2010HD). A quantitative comparison was performed between pre\u2010HD and sym\u2010HD. Meta\u2010regression analyses were used to explore the effects of genetic and clinical features on GMV changes. Twenty\u2010eight studies were included, comparing a total of 1811 HD mutation carriers [including 1150 pre\u2010HD and 560 sym\u2010HD] and 969 healthy controls (HCs). Pre\u2010HD showed decreased GMV in the bilateral caudate nuclei, putamen, insula, anterior cingulate\/paracingulate gyri, middle temporal gyri, and left dorsolateral superior frontal gyrus compared with HCs. Compared with pre\u2010HD, GMV decrease in sym\u2010HD extended to the bilateral median cingulate\/paracingulate gyri, Rolandic operculum and middle occipital gyri, left amygdala, and superior temporal gyrus. Meta\u2010regression analyses found that age, mean lengths of CAG repeats, and disease burden were negatively associated with GMV atrophy of the bilateral caudate and right insula in all HD mutation carriers. This meta\u2010analysis revealed the pattern of GMV changes from pre\u2010HD to sym\u2010HD, prompting the understanding of HD progression. The pattern of GMV changes may be biomarkers for disease progression in HD.<\/jats:p>","DOI":"10.1002\/jnr.25366","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T08:38:32Z","timestamp":1719909512000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Gray matter alterations in Huntington's disease: A meta\u2010analysis of\n                    <scp>VBM<\/scp>\n                    neuroimaging studies"],"prefix":"10.1002","volume":"102","author":[{"given":"Xi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, West China Hospital Sichuan University  Chengdu Sichuan 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