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Clinical studies have indicated effects of prenatal cannabis exposure on birth weight, substance use, and neurodevelopmental disorders, but are confounded by several difficult to control variables. Animal models allow for examination of the mechanism of cannabis\u2010induced changes in neurodevelopment and behavior, while controlling dose and timing. Several animal models of prenatal cannabis exposure exist which provide varying levels of construct validity, control of dose, and exposure to maternal stress. Using a voluntary oral consumption model, mouse dams received 5\u2009mg\/kg \u03949\u2010tetrahydrocannabinol (THC) whole cannabis oil in peanut butter daily from gestational day 1 (GD1) to postnatal day 10 (PD10). At GD1, GD18, PD1, PD10, and PD15, maternal plasma was collected; pup brains were collected from GD18 onward. Pup brains had higher levels of THC and cannabidiol at each time point, each of which persisted in maternal plasma and pup brains past the end of treatment (PD15). Male and female adolescent offspring were examined for changes to ventral tegmental area (VTA) dopamine neuron activity and cocaine\u2010seeking behavior. Prenatal and early postnatal (GD1\u2013PD10) cannabis\u2010exposed male, but not female mice had decreased gamma\u2010aminobutyric acid (GABAergic) input, depolarized resting membrane potential, and increased spontaneous firing of VTA dopamine neurons. Cannabis\u2010exposed offspring showed faster decay of N\u2010methyl\u2010D\u2010aspartate (NMDA) currents in both sexes. However, no differences in cocaine\u2010seeking behavior were noted. These data characterize a voluntary prenatal cannabis exposure model and demonstrates VTA dopamine neuronal activity is disinhibited in offspring.<\/jats:p>","DOI":"10.1002\/jnr.25369","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T08:00:49Z","timestamp":1721635249000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Oral pre\u2010 and early postnatal cannabis exposure disinhibits ventral tegmental area dopamine neuron activity but does not influence cocaine preference in offspring in mice"],"prefix":"10.1002","volume":"102","author":[{"given":"Colleen S.","family":"Peterson","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8898-2122","authenticated-orcid":false,"given":"Samantha L.","family":"Baglot","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy, Psychiatry, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0673-2347","authenticated-orcid":false,"given":"Nada A.","family":"Sallam","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Mina","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew N.","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy, Psychiatry, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7546-5687","authenticated-orcid":false,"given":"Stephanie L.","family":"Borgland","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3101-05.2006"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhi076"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-03242-7"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24992"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1911-3326"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(87)90338-3"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.36234"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2930"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2016.05.020"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-47861-8"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881120916135"},{"key":"e_1_2_11_13_1","first-page":"17","article-title":"Stress produced by gavage administration in the rat","volume":"39","author":"Brown A. 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