{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:31:34Z","timestamp":1789018294854,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigated whether the electric field magnitude (E\u2010field) delivered to the left dorsolateral prefrontal cortex (L\u2010DLPFC) changes resting\u2010state brain activity and the L\u2010DLPFC resting\u2010state functional connectivity (rsFC), given the variability in tDCS response and lack of understanding of how rsFC changes. Twenty\u2010one healthy participants received either 2\u2009mA anodal or sham tDCS targeting the L\u2010DLPFC for 10\u2009min. Brain imaging was conducted before and after stimulation. The fractional amplitude of low\u2010frequency fluctuation (fALFF), reflecting resting brain activity, and the L\u2010DLPFC rsFC were analyzed to investigate the main effect of tDCS, main effect of time, and interaction effects. The E\u2010field was estimated by modeling tDCS\u2010induced individual electric fields and correlated with fALFF and L\u2010DLPFC rsFC. Anodal tDCS increased fALFF in the left rostral middle frontal area and decreased fALFF in the midline frontal area (FWE\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.050), whereas sham induced no changes. Overall rsFC decreased after sham (positive and negative connectivity,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001 and 0.020, respectively), with modest and nonsignificant changes after anodal tDCS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.063 and 0.069, respectively). No significant differences in local rsFC were observed among the conditions. Correlations were observed between the E\u2010field and rsFC changes in the L\u2010DLPFC (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.385,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.115), left inferior parietal area (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.495,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.037), and right lateral visual area (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.683,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002). Single\u2010session tDCS induced resting brain activity changes and may help maintain overall rsFC. The E\u2010field in the L\u2010DLPFC is associated with rsFC changes in both proximal and distally connected brain regions to the L\u2010DLPFC.\n                  <\/jats:p>","DOI":"10.1002\/jnr.25378","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T09:00:52Z","timestamp":1725354052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Electric Field Magnitude in the Left Dorsolateral Prefrontal Cortex on Changes in Intrinsic Functional Connectivity Using Transcranial Direct Current Stimulation: A Randomized Crossover Study"],"prefix":"10.1002","volume":"102","author":[{"given":"Eunkyung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Biomedical Research Institute Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seo\u00a0Jung","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Department of Rehabilitation Medicine Seoul National University College of Medicine  Seoul Republic of Korea"},{"name":"Department of Human Systems Medicine Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung\u2010Mo","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Department of Rehabilitation Medicine Seoul National University College of Medicine  Seoul Republic of Korea"},{"name":"Institute on Aging Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6904-7542","authenticated-orcid":false,"given":"Han\u00a0Gil","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Department of Rehabilitation Medicine Seoul National University College of Medicine  Seoul Republic of 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