{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:24:22Z","timestamp":1785795862954,"version":"3.56.0"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2022C03133"],"award-info":[{"award-number":["2022C03133"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870910"],"award-info":[{"award-number":["81870910"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171271"],"award-info":[{"award-number":["82171271"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Assessing the glymphatic system activity using diffusion tensor imaging analysis along with the perivascular space (DTI\u2010ALPS) may be helpful to understand the pathophysiology of moyamoya disease (MMD). 63 adult patients with MMD and 20 healthy controls (HCs) were included for T1\u2010weighted images, T2\u2010FLAIR, pseudocontinuous arterial spin labeling, and DTI. 60 patients had digital subtraction angiography more than 6\u2009months after combined revascularization. The Suzuki stage, postoperative Matsushima grade, periventricular anastomoses (PA), enlarged perivascular spaces (EPVS), deep and subcortical white matter hyperintensities (DSWMH), DTI\u2010ALPS, cerebral blood flow (CBF), and cognitive scales of MMD patients were assessed. MMD patients were divided into early and advanced stage based on the Suzuki stage. We detected lower DTI\u2010ALPS in patients with advanced stage relative to HCs (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.046) and patients with early stage (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004), hemorrhagic MMD compared with ischemic MMD (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.048), and PA Grade 2 compared with Grade 0 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.010). DTI\u2010ALPS was correlated with the EPVS in basal ganglia (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u22120.686,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), Suzuki stage (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u22120.465,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), DSWMH (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u22120.423,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001), and global CBF (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.300,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.017) and cognitive scores (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.343,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.018). The DTI\u2010ALPS of patients with good postoperative collateral formation was higher compared to those with poor postoperative collateral formation (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.038). In conclusion, the glymphatic system was impaired in advanced MMD patients and may affected cognitive function and postoperative neoangiogenesis.\n                  <\/jats:p>","DOI":"10.1002\/jnr.25381","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T08:46:37Z","timestamp":1726476397000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Glymphatic System Impairment in the Advanced Stage of Moyamoya Disease"],"prefix":"10.1002","volume":"102","author":[{"given":"Lingji","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, the Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Clinical Research Center for Neurological Diseases of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwen","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, the Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Clinical Research Center for Neurological Diseases of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxu","family":"Han","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Engineering of Education Ministry, College of Biomedical Engineering and Instrument Science Zhejiang University  Hangzhou China"},{"name":"MOE Frontier Science Center for Brain Science and Brain\u2010machine Integration, School of Brain Science and Brain Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, the Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Clinical Research Center for Neurological Diseases of Zhejiang Province  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Neurological Diseases of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, the Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, the Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiliang","family":"Bai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Engineering of Education Ministry, College of Biomedical Engineering and Instrument Science Zhejiang University  Hangzhou China"},{"name":"MOE Frontier Science Center for Brain Science and Brain\u2010machine Integration, School of Brain Science and Brain Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6449-4930","authenticated-orcid":false,"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, the Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Clinical Research Center for Neurological Diseases of Zhejiang Province  Hangzhou 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