{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T22:31:00Z","timestamp":1725057060336},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":9050,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[1980,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Male rats (25\u201326 days of age) housed with 14 hours of light per day (lights on 0600\u20132000 hours) were either olfactory bulbectomized (rendering them anosmic), bulbectomized plus pinealectomized (Pinx), or left intact. On the day following the operations, intact, anosmic, and anosmic\u2010Pinx animals began receiving single, daily afternoon (1700\u20131800 hours) subcutaneous injections of 50 \u03bcg of melatonin (MEL) for six weeks, while an additional group of intact controls received injections of diluent. At the end of this period, body, anterior pituitary, testicular, and seminal vesicle weights were significantly reduced in intact\u2010MEL\u2010treated animals. Anosmic animals that had been treated with MEL experienced a further, highly significant, 65%, 90%, and 85% depression in testicular, seminal vesicle, and ventral prostate weights, respectively, as compared with intact control and MEL\u2010treated rats. Additionally, both body and anterior pituitary weights were significantly decreased in MEL\u2010treated, anosmic rats. Anosmic\u2010Pinx rats treated with MEL had organ and body weights that were intermediate between those of intact\u2010MEL and anosmic\u2010MEL\u2010treated animals. Pituitary and serum levels of prolactin (Prl) were significantly lower in anosmic\u2010MEL\u2010treated rats than in intact or intact\u2010MEL\u2010treated groups. Similarly, Prl levels were depressed in the anosmic\u2010Pinx rats treated with MEL; however, serum Prl was not statistically lower than in intact or intact\u2010MEL\u2010treated animals. These results indicate that anosmic male rats have an increased sensitivity to antigonadotrophic and Prl\u2010inhibitory effects of MEL. Furthermore, the data suggest that the presence of the pineal gland in anosmic rats is important in permitting anosmia maximally to sensitize the neuroendocrine\u2010reproductive axis to the antigonadotrophic effects of exogenously administered MEL.<\/jats:p>","DOI":"10.1002\/jnr.490050204","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T11:45:57Z","timestamp":1104579957000},"page":"129-136","source":"Crossref","is-referenced-by-count":8,"title":["An interaction between the pineal gland and olfactory deprivation in potentiating the effects of melatonin on gonads, accessory sex organs, and prolactin in male rats"],"prefix":"10.1002","volume":"5","author":[{"given":"David E.","family":"Blask","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline L.","family":"Nodelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000122712"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000122951"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-99-1-152"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-104-1-82"},{"key":"e_1_2_1_6_1","first-page":"30","volume-title":"Anatomical Neuroendocrinology","author":"Heimer L","year":"1974"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091530103"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-89-4-1020"},{"key":"e_1_2_1_9_1","volume-title":"Pineal Chemistry","author":"Quay WF","year":"1974"},{"key":"e_1_2_1_10_1","first-page":"519","volume-title":"Handbook of Physiology, Endocrinology IV","author":"Reiter RJ","year":"1974"},{"key":"e_1_2_1_11_1","volume-title":"The Pineal \u2013 1977","author":"Reiter RJ","year":"1977"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000122427"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0190563"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000122019"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-88-4-895"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000122616"},{"key":"e_1_2_1_17_1","first-page":"S211","article-title":"Ultrastructural evidence for a central innervation of the rat pineal gland","volume":"1","author":"R\u00f8nnekleiv OK","year":"1978","journal-title":"Neurosci Lett"},{"key":"e_1_2_1_18_1","first-page":"340","article-title":"Serotoninergic control of rat growth hormone secretion","volume":"17","author":"Symthe GA","year":"1975","journal-title":"Neuroendocrinology"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.563102"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.490050204","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.490050204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T06:22:13Z","timestamp":1699770133000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.490050204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,1]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1980,1]]}},"alternative-id":["10.1002\/jnr.490050204"],"URL":"https:\/\/doi.org\/10.1002\/jnr.490050204","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,1]]}}}