{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T11:17:35Z","timestamp":1758280655892},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":8684,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A method has been developed for the complete extraction and fractionation of the autofluorescent lipopigments present in the neuronal tissue of Batten\u2010Spielmeyer\u2010Vogt (BSV) patient and normal subject, respectively. The fluorescent lipopigments that were about three\u2010fold higher in BSV patient's brain as compared with normal subjects were separated into at least 7 fluorometrically and chromatographically distinct fractions by thin layer chromatography (TLC). Although the fluorescent lipopigments of the brain tissue of BSV patient and normal subject showed identical pattern of separation on TLC, the fluorescence spectra of the individual lipopigment fractions from BSV patient was different from those of the corresponding fractions from the normal subject. The ultraviolet spectral studies with individual fluorescent lipopigment fractions indicated the presence of highly unsaturated conjugated chromophore.<\/jats:p>","DOI":"10.1002\/jnr.490060611","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T10:04:13Z","timestamp":1104573853000},"page":"771-783","source":"Crossref","is-referenced-by-count":8,"title":["Studies in neuronal ceroid\u2010lipofuscinosis: Heterogeneous nature of neuronal autofluorescent lipopigments"],"prefix":"10.1002","volume":"6","author":[{"given":"Hari S.","family":"Garg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yogesh C.","family":"Awasthi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satish K.","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1091667"},{"key":"e_1_2_1_3_1","first-page":"3","article-title":"Deficient leukocyte peroxidase activity in the Batten\u2010Spielmeyer\u2010Vogt syndrome","volume":"98","author":"Armstrong D","year":"1973","journal-title":"Trans Am Neurol Assoc"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1974.00490320032004"},{"key":"e_1_2_1_5_1","first-page":"770","article-title":"Studies in neuronal ceroid\u2010lipofuscinosis. Leukocyte peroxidase deficiency in a patient with neuronal ceroid\u2010lipofuscinosis (Jansky\u2010Bielschowsky type)","volume":"59","author":"Awasthi YC","year":"1977","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_6_1","first-page":"386","article-title":"Cerebral degeneration with symmetrical changes in the maculae in two members of a family","volume":"23","author":"Batten FE","year":"1903","journal-title":"Trans Ophthalmol Soc UK"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02544636"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(64)90008-5"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(64)90009-7"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00835a019"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00688393"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00434042"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00688557"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(73)90327-8"},{"key":"e_1_2_1_15_1","unstructured":"GargHS WANeff YCAwasthi SKSrivastava(1981): Studies in neuronal ceroid lipofuscinosis: Enzymes of liver and brain tissues involved in the defense against oxidative damage.J Lab Clin Med.Communicated."},{"key":"e_1_2_1_16_1","first-page":"151","article-title":"GM2\u2010gangliosidoses (amaurotic idiocies) type I, II, and III","volume":"71","author":"Karbe E","year":"1973","journal-title":"Am J Pathol"},{"key":"e_1_2_1_17_1","first-page":"536","article-title":"Defense of mouse red blood cells against oxidative damage by phenylhydrazine","volume":"95","author":"Lal AK","year":"1980","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(76)80023-9"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/23.2.145"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(65)90053-7"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02535833"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2944(70)90064-5"},{"key":"e_1_2_1_23_1","first-page":"620","article-title":"Wietere Mitteilung uber eine bescondere Form von Familiarer amaurotische","volume":"24","author":"Spielmeyer W","year":"1905","journal-title":"Idiotie Neurol Zbl"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02532441"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02532722"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000213427"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.841336"},{"key":"e_1_2_1_28_1","first-page":"470","article-title":"Neuronal ceroid\u2010lipofuscinosis (Batten Disease) relationship to amaurotic familiar idiocy","volume":"44","author":"Zeman W","year":"1968","journal-title":"Pediatrics"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197401000-00001"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.490060611","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.490060611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T03:32:04Z","timestamp":1699759924000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.490060611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1002\/jnr.490060611"],"URL":"https:\/\/doi.org\/10.1002\/jnr.490060611","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}