{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:07:59Z","timestamp":1765267679167},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":7589,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present study examined proteins and glycoproteins from an axolemma\u2010enriched fraction from the developing offspring of female rats that were pair\u2010fed control or 6.6% (50 g\/liter) ethanol liquid diets on a chronic basis prior to parturition. In addition, this study examined the synthesis of the major CNS myelin\u2010associated glycoprotein (MAG) as an index of myelin maturation. The results of the latter study demonstrated normal MAG maturation in ethanol\u2010treated rats. However, a significant decrease in the proportion of radioactivity associated with MAG was found in the developing offspring of ethanol\u2010treated rats.<\/jats:p><jats:p>The major axolemmal proteins from 32\u2010day rats included those with molecular weights of 105 K, 81 K, 62 K, 55 K, 52 K, 36 K, and 33 K. Major peaks of radioactivity were associated with fucosylated axolemmal glycoproteins with apparent molecular weights of 150 K, 130 K, 85 K, 76 K, and 64 K. Several development\u2010related changes in the protein composition of axolemma\u2010enriched fractions were observed in control animals. Between 22 and 32 days of age control rats exhibited a significant (P &lt;.05) decrease in the proportion of axolemmal proteins that had apparent molecular weights of 150 K, 105 K, and 62 K. A development\u2010related decrease in the 105 K axolemma\u2010associated protein did not occur during the 22\u201332\u2010day age period in the offspring of ethanol\u2010treated animals. At 22 days the proportion of this 105 K protein in affected offspring was significantly (P &lt;.05) less than that in age\u2010matched control rats and comparable to that in 32\u2010day control rats. The relative distribution of radioactivity among fucosylated axolemmal glycoproteins also changed significantly between 22 and 32 days of age. These changes include a decrease in the proportion of radioactivity associated with the 110 K, 55 K, and 52 K fucosylated glycoproteins and an increase in the proportion of radioactivity associated with the 85 K and 67 K glycoproteins. Several small, but significant (P &lt;.05) alterations were found associated with glycoproteins in an axolemma\u2010enriched fraction from 22\u2010 and 32\u2010day ethanoltreated rats.<\/jats:p>","DOI":"10.1002\/jnr.490120412","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T05:23:41Z","timestamp":1104557021000},"page":"633-645","source":"Crossref","is-referenced-by-count":19,"title":["Glycoproteins and proteins in an axolemma\u2010enriched fraction and myelin from developing rats: Effect of maternal ethanol consumption"],"prefix":"10.1002","volume":"12","author":[{"given":"J. M.","family":"Gnaedinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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