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Using quantitative techniques of receptor autoradiography, an increase in muscarinic receptor binding was demonstrated in such regions as the corpus callosum, lamina VI of the parietal cortex, caudate\u2010putamen, ventral nucleus of the thalamus, stratum lacunosum moleculare and stratum oriens of the hippocampus, and the hilus of the area dentata. As a result of thiamine deficiency, this increase in muscarinic receptor populations was primarily due to an increase in the binding of the low\u2010affinity agonist site. In the same experiment, a decrease in muscarinic receptor binding was found in the ventromedial region of the hypothalamus. Thiamine deficiency thus causes an up\u2010regulation of muscarinic receptor binding in several regions of rat brain while causing a down\u2010regulation of these same receptors in other brain areas.<\/jats:p>","DOI":"10.1002\/jnr.490130310","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T10:26:12Z","timestamp":1104575172000},"page":"443-452","source":"Crossref","is-referenced-by-count":9,"title":["Alterations in muscarinic cholinergic receptor densities induced by thiamine deficiency: Autoradiographic detection of changes in high\u2010 and low\u2010affinity agonist binding"],"prefix":"10.1002","volume":"13","author":[{"given":"D.R.","family":"Gehlert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.A.","family":"Morey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.K.","family":"Wamsley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(73)90087-3"},{"key":"e_1_2_1_3_1","first-page":"464","article-title":"Effects of alcohol and amobarbitol on performance inhibited by experimental extinction","volume":"55","author":"Barry H.","year":"1962","journal-title":"J Comp Physiol"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7046051"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1976.tb01536.x"},{"key":"e_1_2_1_6_1","first-page":"25","volume-title":"Cholinergic Mechanisms and Psychopharmacology","author":"Birdsall N. 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