{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T10:42:39Z","timestamp":1697884959493},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":7223,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present investigation sought to examine the importance of substance P in the altered respiratory activity after neonatal capsaicin administration. Halothaneanesthetized adult rats given capsaicin neonatally exhibit a decreased basal minute ventilation with PaCO<jats:sub>2<\/jats:sub> equal to and PaO<jats:sub>2<\/jats:sub> greater than vehicle injected controls. In addition, the minute ventilation\u2010PaCO<jats:sub>2<\/jats:sub> curve was displaced to the right. Acute bilateral cervical vagotomy severely blunted the minute ventilation response to PaCO<jats:sub>2<\/jats:sub> and abolished the differences in ventilation between capsaicin treated and control rats. Neonatal capsaicin significantly reduced pons\u2010medulla substance P content but not TRH, serotonin or 5\u2010hydroxyindole acetic acid. Immunohistochemical studies revealed that substance P fibers of the trigeminal spinal nucleus were the most severely affected in the brain stem and that substance P fibers in the lung were totally absent.<\/jats:p><jats:p>The intracerebroventricular administration of substance P increased minute ventilation similarly in both control and capsaicin treated rats, largely as a result of increases in tidal volume. The minute ventilation\u2010PaCO<jats:sub>2<\/jats:sub> curve was similar in both groups after substance P administration. Simultaneous administration of the peptidase inhibitor captopril with substance P increased the respiratory response to substance P in normal rats. Administration of captopril to capsaicin treated rats restored the ventilation\u2010PaCO<jats:sub>2<\/jats:sub> curve to the position observed in normal rats. The hypotensive response to intracerebroventricular captopril alone in control rats was less profound in rats given neonatal capsaicin.<\/jats:p><jats:p>These results are consistent with the thesis that respiratory depression after capsaicin treatment is at least in part due to the loss of substance P primary afferent nerve terminals in the brain stem, suggesting that substance P fibers in the brain stem may participate in the normal modulation of respiratory activity.<\/jats:p>","DOI":"10.1002\/jnr.490140209","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T10:29:07Z","timestamp":1104575347000},"page":"239-253","source":"Crossref","is-referenced-by-count":4,"title":["Altered respiratory response to substance P in capsaicin\u2010treated rats"],"prefix":"10.1002","volume":"14","author":[{"given":"A. C.","family":"Towle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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