{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:54:44Z","timestamp":1715536484252},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":7223,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The high\u2010affinity bindings of [<jats:sup>3<\/jats:sup>H]\u20105\u2010hydroxytryptamine to serotonin S\u2010l receptors, [ H]\u2010ketanserin to serotonin S\u20102 receptors in the cerebral cortex, [<jats:sup>3<\/jats:sup>H]\u2010fluphenazine to dopamine D\u2010l receptors, and [<jats:sup>3<\/jats:sup>H]\u2010spiroperidol to dopamine D\u20102 receptors in the corpus striatum were studied in pyridoxine\u2010deficient rats and compared to pyridoxine\u2010supplemented controls. There was a significant increase in the maximal binding (B<jats:sub>max<\/jats:sub>) of serotonin S\u2010l and S\u20102 receptors with a significant decrease in their binding affinities (K<jats:sub>d<\/jats:sub>). However, there were no significant changes either in the maximal binding or binding affinity of striatal dopamine D\u20101 and D\u20102 receptors. Receptor sensitivity seems to correlate negatively with the corresponding neurotransmitter concentrations in the pyridoxine\u2010deficient rats.<\/jats:p>","DOI":"10.1002\/jnr.490140211","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T10:29:07Z","timestamp":1104575347000},"page":"263-270","source":"Crossref","is-referenced-by-count":22,"title":["Effect of pyridoxine deficiency in young rats on high\u2010affinity serotonin and dopamine receptors"],"prefix":"10.1002","volume":"14","author":[{"given":"C. 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