{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T16:50:59Z","timestamp":1697907059065},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":7223,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We examined the ability of nitrendipine, a calcium antagonist believed to block the voltage\u2010sensitiv calcium channels in a number of excitable membranes, to affect the calcium spike duration and rate of rise (Dv\/Dt) in 4\u2010week\u2010old cultured mouse dorsal root ganglion neurous. Concentrations of 10 nM\u20101:0 \u03bcM intrendipine reduced but did not eliminate calcium spike as measured by the rate of rise. These results were obtained at either 22\u00b0 rate of rise (Dv\/Dt) in 4\u2010week\u2010old cultured mouse dorsal root ganglion neurous. Concentrations of 10 nM\u20101:0 \u03bcM intrendipine reduced but did not eliminate calcium spike as measured by the rate of rise. These results were obtained at either 22\u00b0 or 37\u00b0C in solutions containing 5 mM calcium. A similar lack of total block was seen with prolonged incubation in sodium\u2010free recording media containing 1 \u03bcM tetrodotoxin (TTX), 1.8 mM calcium, and 1 \u03bcM nitrendipine. Calcium spike duration was affected in an inconsistent manner by nitrendipine and other 1,4 dihydropyridines. Cobalt (10 mM) totally blocked the voltage\u2010dependent calcium mechanism as measured by either the spike duration or the rate of rise. We conclude that calcium influx through the voltage\u2010sensitive calcium channel in mouse dorsal root ganglion neurons is not blocked by even high concentrations of nitrendipine.<\/jats:p>","DOI":"10.1002\/jnr.490140404","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T10:31:53Z","timestamp":1104575513000},"page":"415-422","source":"Crossref","is-referenced-by-count":4,"title":["Effects of nitrendipine on the voltage\u2010sensitive calcium channel in mammalian sensory neurons"],"prefix":"10.1002","volume":"14","author":[{"given":"M. J.","family":"Litzinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. G.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Y. K.","family":"Pun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1983.tb00845.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014186"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1523\/JNEUROSCI.04-06-01453.1984","article-title":"Identification and characterization of voltagesensitiv calcium channels in neuronal clonal cell lines","volume":"4","author":"Freedman SB","year":"1984","journal-title":"J Neurosci"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/311538a0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)91234-8"},{"key":"e_1_2_1_7_1","first-page":"169","volume-title":"Nitrendipine","author":"Lee KS","year":"1984"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(84)91054-4"},{"key":"e_1_2_1_9_1","unstructured":"LitzingerMJ BrennemanDE(1984b): [H3]\u2010Nitrendipine binding in developing dissociated fetal mouse spinal cord neurons.Biochem Biophys Res Commun(in press)."},{"key":"e_1_2_1_10_1","first-page":"579","article-title":"The effects of some organic \u201ccalcium antagonists\u201d on calcium influx in presynaptic nerve teminals","volume":"16","author":"Nachshen DA","year":"1979","journal-title":"Mol Pharmacol"},{"key":"e_1_2_1_11_1","first-page":"53","article-title":"Actions of calcium antagonists on calcium currents in Helix neurons","volume":"52","author":"Nishi K","year":"1983","journal-title":"Circ Res"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(82)90122-5"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)91101-6"},{"key":"e_1_2_1_14_1","first-page":"526","article-title":"Does nitrendipine block calcium channels in neuronal preparations?","volume":"10","author":"Pun RYK","year":"1984","journal-title":"Neurosci Abstr"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1984.tb06096.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90069-5"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.490140404","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.490140404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T04:40:23Z","timestamp":1697776823000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.490140404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,1]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1985,1]]}},"alternative-id":["10.1002\/jnr.490140404"],"URL":"https:\/\/doi.org\/10.1002\/jnr.490140404","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,1]]}}}