{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:00:15Z","timestamp":1771628415007,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":6493,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In order to determine the possible effects of interleukin\u20101 on the release of pituitary hormones by direct action on the brian, the peptide was injected into the third brain ventricle of conscious, unrestrained male rats and the effects on hormone release were compared with effects on rectal temperature. The procedure of blood sampling and intraventricular injection resulted in a significant decline in body temperature and a decrease in plasma growth hormone without alteration in the plasma level of thyroid stimulating hormone (TSH) and prolactin. Interleukin\u20101 injected intraventricularly at a dose of 5 ng (0.3 pmol) prevented the decline in body temperature that occurred in the saline\u2010injected controls and resulted in a significant elevation of plasma growth hormone levels that became apparent within 15 min of injection, as well as a highly variable but significant elevation of plasma prolactin and a significant decline in plasma TSH that was observed at 30 min. The results were similar when areas under the release curves for the various hormones were calculated. On the other hand, the higher dose of 25 ng (1.5 pmole) of interleukin\u20101, although producing a frank pyrexia, was associated with smaller changes in hormone values, which were no longer significant for any of the three hormones. The results indicate that interleukin\u20101 can act in minute doses, presumably on structures near the third ventricle, to stimulate growth homone and prolactin release and to inhibit TSH releas. Apparently when frank febrile responses occur, these hormonal responses are muted for reasons that are yet to be determined. In view of the minute doses injected we favor a hypothalamic site for these effects.<\/jats:p>","DOI":"10.1002\/jnr.490180125","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T01:32:26Z","timestamp":1104543146000},"page":"179-183","source":"Crossref","is-referenced-by-count":90,"title":["Central action of interleukin\u20101 in altering the release of tsh, growth hormone, and prolactin in the male rat"],"prefix":"10.1002","volume":"18","author":[{"given":"V.","family":"Rettori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Jurcovicova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M.","family":"McCann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-133-34713"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3014662"},{"key":"e_1_2_1_4_1","first-page":"1","article-title":"Relationships between neuroendocrin hormones and lymphokines","volume":"9","author":"Blalock JE","year":"1984","journal-title":"Lymphokines"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1152\/ajplegacy.1966.210.3.606","article-title":"A comparison of the effects of environmental and preoptic heating and pyrogen on plasma cortisol levels","volume":"210","author":"Chowers I","year":"1966","journal-title":"Am J Physiol"},{"key":"e_1_2_1_6_1","first-page":"437","article-title":"Fever and immunoregulation: Hyperthermia, Interleukin 1 and 2, T\u2010cell proliferation","volume":"55","author":"Duff GW","year":"1982","journal-title":"Yale J Biol Med"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1974.36.3.391"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000122576"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.4049\/jimmunol.124.5.2498","article-title":"Endogenous pyrogens made by rabbit peritoneal exudate cells are identical with lymphocyte activating factors made by rabbit elveolar macrophages","volume":"124","author":"Murphy PA","year":"1980","journal-title":"J Immunol"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000124757"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.490180125","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.490180125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T14:32:00Z","timestamp":1697898720000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.490180125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,1]]}},"alternative-id":["10.1002\/jnr.490180125"],"URL":"https:\/\/doi.org\/10.1002\/jnr.490180125","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1]]}}}