{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T15:21:06Z","timestamp":1697988066625},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":6493,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Seventeen white patients from the Stanford Sleep Disorders Clinic compaining of excessive daytime somnolence (EDS) were selected for restriction\u2010fragment\u2010length polymorphism (RFLP) studies. Fourteen of the patients with clinically diagnosed narcolepsy were seropositive for DR2. RFLP analysis of these patients compared with a homozygous DR2\u2010Dw2 cell line failed to reveal any polymorphism when digested with six restriction endonucleases and hybridized with three different cDNA probes. None of the three patients with central nervous system hypersomnia, a syndrom similar to narcolepsy, were DR2\u2010positive. We conclude that any polymorphism of the DR\u03b2, DQ\u03b1 or DQ\u03b2, genes of DR2 narcoleptics that might distinguish them from DR2 nomals cannot be resolved through RELP analysis.<\/jats:p>","DOI":"10.1002\/jnr.490180134","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T01:32:26Z","timestamp":1104543146000},"page":"239-244","source":"Crossref","is-referenced-by-count":10,"title":["HLA\u2010DR restriction\u2010fragment\u2010length polymorphisms in narcolepsy"],"prefix":"10.1002","volume":"18","author":[{"given":"J. D.","family":"Holloman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. I.","family":"Bell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. S.","family":"Kilduff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. C.","family":"Dement","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Guilleminault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. O.","family":"McDevitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1","article-title":"Diagnostic Classification of Sleep and Arousal disorders","volume":"2","author":"Association of Sleep Disorders Centers","year":"1979","journal-title":"Sleep"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90188-1"},{"key":"e_1_2_1_4_1","first-page":"199","volume-title":"Brain Mechanisms of Slee","author":"Baker TL","year":"1985"},{"key":"e_1_2_1_5_1","first-page":"510","article-title":"HLA abtugebs in Grave's Disease","volume":"86","author":"Bech K","year":"1977","journal-title":"Acta Endocrinol"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.10.3405"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92072-0"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198508083130604"},{"key":"e_1_2_1_9_1","first-page":"45","article-title":"Heredofamilial aspects of narcolepsy and hypersomnia","volume":"110","author":"Bruhova S","year":"1972","journal-title":"Arch suisse Neurol Neurochir\u2010Psychiatr"},{"key":"e_1_2_1_10_1","first-page":"313","volume":"34","author":"Daly D","year":"1959","journal-title":"Proc Staff Meet Mayo Clin"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(86)90068-6"},{"key":"e_1_2_1_12_1","first-page":"254","article-title":"Discrimination of narcoleptic patients by using genetic markers and HLA","volume":"12","author":"Honda Y","year":"1983","journal-title":"Sleep Res"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/9.1.133"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00377973"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1984.tb02144.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1974.tb02796.x"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","unstructured":"LandgonN Van DamM WelshKI VaughanRW ParkesD(1984):Genetic markers in narcolepsy. Lancet:1178\u20131180.","DOI":"10.1016\/S0140-6736(84)92742-9"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/sleep\/9.1.143","article-title":"Immune factors in narcolepsy","volume":"9","author":"Langdon N","year":"1986","journal-title":"Sleep"},{"key":"e_1_2_1_19_1","series-title":"Proc Natl Acad Sci USA","volume-title":"HLA\u2010DR2 subtypes form and additional supertypic family of DR\u03b2 alleles","author":"Lee BSM","year":"1987"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","unstructured":"LeeBSM BellJI RustNA McDevittHO(1987b):Structural and functinal variability among DQ\u03b2 alleles of DR2 subtypes Immunogenetics (in press).","DOI":"10.1007\/BF00345459"},{"key":"e_1_2_1_21_1","first-page":"148","article-title":"Human leucocyte antigen (HLA) studies in excessive somnolence: Narcolepsy versus sleep apnea","volume":"15","author":"Mitler MM","year":"1986","journal-title":"Sleep Res"},{"issue":"1","key":"e_1_2_1_22_1","first-page":"299","article-title":"HLA antigens in narcolepsy","volume":"36","author":"Neeley SE","year":"1986","journal-title":"Neurology"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1399-0039.1984.tb00031.x","article-title":"Possible association between HLA \u2010B7 and narcolepsy","volume":"23","author":"Seignalet J","year":"1984","journal-title":"Tissue Antigens"},{"key":"e_1_2_1_23_1","first-page":"1432","article-title":"Maladie associ\u00e9ne tissulaire HLA\u20103","volume":"4","author":"Simon M","year":"1975","journal-title":"Nouv Presse Med"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(75)80083-0"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1985.tb00958.x"},{"issue":"1089","key":"e_1_2_1_26_1","first-page":"1093","article-title":"Two genes encoding steroid 21 hydroxylase are located near the genes encoding the fourth component of complement in man","volume":"82","author":"White PC","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_2_1_27_1","first-page":"239","article-title":"Hereditary aspects of narcolepsy","volume":"85","author":"Yoss RA","year":"1960","journal-title":"Trans Am Neurol Assoc"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.490180134","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.490180134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T14:30:27Z","timestamp":1697898627000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.490180134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,1]]}},"alternative-id":["10.1002\/jnr.490180134"],"URL":"https:\/\/doi.org\/10.1002\/jnr.490180134","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1]]}}}