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Acetylcholine (3\u2010100 \u03bcM) or carbachol (30\u20101,000 \u03bcM) induced the hydrolysis of prelabeled polyphosphoinositides and, at the same time, stimulated the net label incorporated in phosphatidic acid. All muscarinic effects were blocked by atropine or pirenzepine. Nonmuscarinic agonists (glutamate, adenosine, norepinephrine) stimulated polyphosphoinositide hydrolysis in this preparation, but of these only norepinephrine affected phosphatidic acid turnover. A Potentiation of acetylcholine\u2010induced phosphoinositide turnover by KCI was observed, as well as an apparent selective inhibition of PIP2 hydrolysis by LiCl. Acetylcholinestimulated turnover of PA was not necessarily coupled to phosphoinositide hydrolysis.<\/jats:p>","DOI":"10.1002\/jnr.490200117","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T01:38:02Z","timestamp":1104543482000},"page":"122-128","source":"Crossref","is-referenced-by-count":5,"title":["Effects of acetylcholine and other agents on <sup>32<\/sup>P\u2010prelabeled phosphoinositides and phosphatidate in crude synaptosomal preparations"],"prefix":"10.1002","volume":"20","author":[{"given":"H. 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