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Transgenic mice harboring the same transgene in a (SV11\u2010C57Bl\/6J \u00d7 NZW\/lacJ) F1 genetic background express considerably lower levels of the transgene mRNA at comparable times after birth. As a consequence, tumor development and death are delayed. The NZW mice appear to contribute a dominant negative regulator for the expression of the SV40 large T antigen transgene, which in turn has a dramatic effect upon the time of appearance of tumors and the death of these transgenic animals.<\/jats:p>","DOI":"10.1002\/jnr.490240116","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T01:45:52Z","timestamp":1104543952000},"page":"115-122","source":"Crossref","is-referenced-by-count":14,"title":["Impact of the genetic background of transgenic mice upon the formation and timing of choroid plexus papillomas"],"prefix":"10.1002","volume":"24","author":[{"given":"H. 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