{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T10:51:52Z","timestamp":1774867912158,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":5277,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The distribution of cerebellar gangliosides was studied in Purkinje cell degeneration <jats:italic>(pcd\/pcd)<\/jats:italic> mutant mice at postnatal days 25, 30, 50, and 150. These mutants lose the majority of Purkinje cells between 18 and 50 days of age. A reactive gliosis accompanies Purkinje cell loss and a partial loss of granule cells occurs in <jats:italic>pcd\/pcd<\/jats:italic> mice older than p50. Purkinje cell loss is associated with significant reductions in cerebellar weight and ganglioside concentration. This neuronal loss was also developmentally correlated with reductions of gangliosides GT1a\/LD1 and GT1b and with elevations of GD3. These results agree with previous findings in other cerebellar mutants that GT1a\/LD1 and GT1b are concentrated in Purkinje cells and that GD3 is enriched in reactive glial cells. A slight, but significant, reduction in GD1a concentration occurred only in older <jats:italic>pcd\/pcd<\/jats:italic> mice, consistent with previous findings in weaver and staggerer mice that GD1a is enriched in mature granule cells. The findings with <jats:italic>pcd\/pcd<\/jats:italic> and other neurological mutants indicate that certain gangliosides can serve as cell\u2010surface markers for monitoring changes in cerebellar cytoarchitecture that accompany development or disease.<\/jats:p>","DOI":"10.1002\/jnr.490260113","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T05:35:08Z","timestamp":1104557708000},"page":"105-111","source":"Crossref","is-referenced-by-count":13,"title":["Cerebellar ganglioside abnormalities in <i>pcd<\/i> mutant mice"],"prefix":"10.1002","volume":"26","author":[{"given":"T. N.","family":"Seyfried","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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