{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T21:14:49Z","timestamp":1698009289717},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":5277,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An attempt was made to use the pineal gland as a model for the study of the primary mode of action of alpha\u2010methyldopa, which is still unclear. Organ cultures of pineal glands from rats treated chronically with alpha\u2010methyldopa showed enhanced conversion or radio\u2010active serotonin to melatonin (aMT) as well as its precursor, N\u2010acetyl\u2010serotonin (aHT). This treatment was also found to raise serotonin\u2010N\u2010acetyltransferase (NAT) activity. Thse increases associated with alpha\u2010methyldopa treatment were further enhanced by the beta\u2010adrenergic agonist, isoproterenol, suggesting a supersensitivity\u2010type effect occurring at the level of the beta\u2010receptor. A subsequent binding study, however, showed a decrease in betareceptor binding with exposure to alpha\u2010methyldopa, providing mitigating eveidence against the occurrence of a supersensitivity phenomenon. It is possible that a metabolite of alpha\u2010methyldopa acts as an alpha 1 and beta\u2010agonist, resulting in greater melatonin (aMT) and N\u2010acetylserotonin (aHT) synthesis than by a beta\u2010agonist, isoproterenol.<\/jats:p>","DOI":"10.1002\/jnr.490260115","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T05:35:08Z","timestamp":1104557708000},"page":"115-119","source":"Crossref","is-referenced-by-count":0,"title":["Pineal gland as a model to elucidate the primary mode of action of alpha\u2010methyldopa: Alpha\u2010methyldopa induces an increase in the synthesis of N\u2010acetylserotoni and melatonin levels by the rat pineal gland"],"prefix":"10.1002","volume":"26","author":[{"given":"A. D.","family":"Welman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Daya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1980.tb04624.x"},{"key":"e_1_2_1_3_1","first-page":"21","article-title":"Effect of long\u2010term changes in sympathetic nervous activity on the beta\u2010adrenergic receptor\u2010adenylate cyclase complex of rat pineal gland","volume":"19","author":"Cantor EH","year":"1981","journal-title":"Mol Pharmacol"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(72)90496-4"},{"key":"e_1_2_1_5_1","first-page":"23","volume-title":"Proceedings of the Workshop on the Pineal Gland","author":"Ebadi M","year":"1986"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(69)90290-5"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.2.599"},{"key":"e_1_2_1_8_1","first-page":"784","volume-title":"The Pharmacological Basis of Therapeutics","author":"Rudd P","year":"1985"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(84)90006-6"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00964540"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.490260115","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.490260115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T20:55:12Z","timestamp":1698008112000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.490260115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,5]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,5]]}},"alternative-id":["10.1002\/jnr.490260115"],"URL":"https:\/\/doi.org\/10.1002\/jnr.490260115","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,5]]}}}