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Specific L\u2010[<jats:sup>3<\/jats:sup>H]glutamate binding was higher in the molecular than in the granule cell layer of normal cerebellar tissue. A significant decrease of L\u2010[<jats:sup>3<\/jats:sup>H]glutamate specific binding was observed in me molecular layer of ail OPCA tissues. In the granule cell layer L\u2010[<jats:sup>3<\/jats:sup>H]glumate binding was decreased only in two patients who suffered from late\u2010onset sporadic OPCA and in one patient who suffered from a form of OPCA inherited in a dominant manner.<\/jats:p><jats:p>Quisqualate\u2010sensitive binding sites were the most abundant binding sites in the molecular layer of normal cerebella, whereas N\u2010methyl\u2010D\u2010aspartic acid (NMDA)\u2010sensitive binding sites were the most abundant type in the granule cell layer. A significant decrease of quisqualate\u2010sensitive and an increase in NMDA\u2010sensitive binding sites were observed in the molecular layer of OPCA cerebellar tissues. No significant changes were observed in the granule cell layer of these tissues.<\/jats:p>","DOI":"10.1002\/jnr.490280308","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T05:43:57Z","timestamp":1104558237000},"page":"367-375","source":"Crossref","is-referenced-by-count":7,"title":["Quantitative autoradiographic study of L\u2010glutamate binding sites in normal and atrophic human cerebellum"],"prefix":"10.1002","volume":"28","author":[{"given":"A.","family":"Hatziefthimiou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Mitsacos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Mitsaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Plaitakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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