{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:35:49Z","timestamp":1784345749732,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":4912,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[1991,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The long\u2010chain fatty alcohol, n\u2010hexacosanol, has been shown to possess neurotrophic properties in vitro on rat CNS cultures (Borg et al., 1987) and to promote the survival of septal cholinergic neurons after experimental axotomy (Borg et al., 1990). Long\u2010chain alcohols have also been shown to be synthesized and metabolised by rat brain during development (Bishop and Hayra, 1981; Natarajan et al., 1984). The present study was undertaken in order to find out if a nonproteic neurotrophic factor like n\u2010hexacosanol may be able to reduce the neuronal damages induced by the excitatory amino acid, kainic acid. When administered chronically by intraperitoneal injection, hexacosanol (1 mg\/kg) protected the pyramidal neurons of the hippocampus from the neurotoxic degeneration induced by an intracerebroventricular infusion of kainic acid in rats; the extent of the damage was limited to a small part of the CA3 region. Mor\u2010phometric analysis showed that 72% of the neurons that would have died following kainic acid injection were spared by hexacosanol. Moreover the increased locomotor activity induced by the neurotoxin was also inhibited by hexacosanol and the behavioral effect was statistically correlated to the extent of neuronal loss. The present study suggests a possible role for nonproteic neurotrophic compounds against neurotoxic damages on central neurons. Moreover the peripheral administration of hexacosanol may lead to a significant breakthrough in the treatment of excito\u2010toxin\u2010related human diseases.<\/jats:p>","DOI":"10.1002\/jnr.490290107","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T05:50:12Z","timestamp":1104558612000},"page":"62-67","source":"Crossref","is-referenced-by-count":12,"title":["The neurotrophic factor, n\u2010hexacosanol, reduces the neuronal damage induced by the neurotoxin, kainic acid"],"prefix":"10.1002","volume":"29","author":[{"given":"Jacques","family":"Borg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"612","article-title":"Efficacy of baclofen and phenobarbital against the kainic acid limbic seizure brain damage syndrome","volume":"239","author":"Ault B","year":"1986","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(85)90299-4"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90571-7"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)68796-X"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90985-K"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(87)81531-4"},{"key":"e_1_2_1_8_1","first-page":"1","volume-title":"Handbook of Chemical Neuroanatomy","author":"Butcher LL","year":"1983"},{"key":"e_1_2_1_9_1","unstructured":"Camacho\u2010OchoaM JacksonTA AaronCS Von VoigtlanderPF(1987): Antagonism of kainic acid lesions in the mouse hippocampus by U\u201050488H. 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