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It is most prevalent during development on cell bodies of migrating neurons and on axons during formation of nerves. Ng\u2010CAM expression is greatly increased following nerve injury. Anti\u2010Ng\u2010CAM antibodies inhibited migration of granule cells along Bergmann glia in cerebellar explants and fasciculation of neurites in outgrowths from explants of dorsal root ganglia. The combined results indicate that Ng\u2010CAM on neurons binds to Ng\u2010CAM on adjacent neurons and to as yet unidentified ligands on astrocytes.<\/jats:p><jats:p>Ng\u2010CAM is synthesized in chicken neurons from a 6 kb mRNA as Mr \u223c200,000 forms which are cleaved to yield two components of Mr 135,000 and 80,000. It is glycosylated and can be phosphorylated. Amino acid sequence analysis indicates that it contains six immunoglobulin domains, five fibronec\u2010tin type III repeats, a transmembrane domain and a cytoplasmic region. Structural analyses indicate that Ng\u2010CAM is most closely related to the mammalian glycoprotein L1 but significant differences between them strongly suggest that they are not equivalent molecules. 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