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CPZ and W\u20107 also significantly inhibited LDL\u2010 and non\u2010LDL\u2010 dependent cholesterol esterification. Addition of these drugs to cell culture medium mimicked what is observed in the genetic disease Niemann\u2010Pick type C.H\u20107 (1\u2010[5\u2010isoquinonylsulfonyl]\u20102\u2010methylpiperazine), an inhibitor of protein kinase C and cyclic nucleotide\u2010dependent kinases, had no effect on sphingomyelinase and cholesterol ester formation. Thus the possibility of a modulation of cell sphingomyelin and cholesterol esters by a calmodulin\u2010dependent second messenger system must be considered.<\/jats:p>","DOI":"10.1002\/jnr.490310112","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T04:12:45Z","timestamp":1104552765000},"page":"84-88","source":"Crossref","is-referenced-by-count":22,"title":["Calmodulin antagonists chlorpromazine and W\u20107 inhibit exogenous cholesterol esterification and sphingomyelinase activity in human skin fibroblast cultures. 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