{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T08:42:58Z","timestamp":1695890578717},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":4136,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[1993,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The distribution of 110\/140 laminin\u2010binding protein (110\/140 LBP) in the spinal dorsal root ganglia (DRG) and its regulation by partial constriction of the sciatic nerve was studied in adult rats. The cross\u2010sectional area of neurons with 110\/140 LBP\u2010immunoreactivity (\u2212I) showed an approximately normal frequency distribution. The 110\/140 LBP\u2010I was observed in neuronal cell bodies exclusive of the nucleus. Following sciatic nerve constriction, the 110\/140 LBP\u2010I was downregulated in the ipsilateral L4\u20105 DRG. DRG neurons with a cross\u2010sectional area \u2265 1600 \u03bcm<jats:sup>2<\/jats:sup> were preferentially affected. Neonatal capsaicin\u2010treatment, a procedure that selectively destroys a subpopulation of DRG neurons with fine unmyelinated axons, had no effect on the reduction of 110\/140 LBP in the DRG induced by sciatic nerve constriction. Western immunoblot analysis confirmed a reduction of 110\/140 LBP on the side ipsilateral to the constriction. These results demonstrate a LBP within primary sensory neurons and its suppression by peripheral nerve injury. The data support a role for LBP in the adult nervous system.\u00a9 1993 WiIey\u2010Liss, Inc.<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#note1\" \/><jats:fn><jats:p>This article is a US Government work and, as such, is in the public domain in the Unitcd States oC America.<\/jats:p><\/jats:fn>\n<\/jats:p>","DOI":"10.1002\/jnr.490350302","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T01:48:59Z","timestamp":1104544139000},"page":"227-236","source":"Crossref","is-referenced-by-count":2,"title":["110\/140 laminin\u2010binding protein immunoreactivity in spinal dorsal root ganglia: A capsaicin\u2010insensitive reduction induced by constriction injury of the sciatic nerve in rats"],"prefix":"10.1002","volume":"35","author":[{"given":"K.","family":"Ren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Kibbey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. K.","family":"Kleinman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Ruda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.1982.240180104"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(91)90229-Q"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90209-6"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90343-R"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91391-0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(89)90020-9"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.106.4.1299"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490080208"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90053-9"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(90)90339-B"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(89)90241-9"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90026-7"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1985.sp015573"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(88)90064-4"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)90356-Z"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1242\/dev.110.3.823","article-title":"Differential expression of laminin A and B chains during development of embryonic mouse organs","volume":"110","author":"Klein G","year":"1990","journal-title":"Development"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240270402"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(91)90547-V"},{"key":"e_1_2_1_20_1","first-page":"315","article-title":"The morphological consequences of neonatal treatment with capsaicinon primary afferent neurones in adult rats","volume":"69","author":"Lawson SN","year":"1987","journal-title":"Acta Physiol Hung"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902430305"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1984.tb01867.x"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.03.110187.000421"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.5.11.1651264"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(92)90037-Q"},{"key":"e_1_2_1_26_1","first-page":"1312","article-title":"GAP\u201043 responses to nerve injury and peripheral inflammation","volume":"17","author":"Nahin RL","year":"1991","journal-title":"Soc Neurosci Asbstr"},{"key":"e_1_2_1_27_1","unstructured":"NahinRL RenK DeLe\u00f3nM RudaMA(1992):Primary sensory neurons exhibit altered gene expression in a rat model of neuropathic pain. Submitted."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903130408"},{"key":"e_1_2_1_29_1","first-page":"288","article-title":"Correlation of axonal numbers and behavioral symptoms in a rat experimental neurophthy model","volume":"18","author":"Pover CM","year":"1992","journal-title":"Soc Neurosci Abstr"},{"key":"e_1_2_1_30_1","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1523\/JNEUROSCI.02-11-01660.1982","article-title":"Immunocytochemical analysis of serotonergic axons in laminae I and II of the lumbar spinal cord of the cat","volume":"2","author":"Ruda MA","year":"1982","journal-title":"J Neurosci"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91723-T"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.9.4350"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90206-O"},{"key":"e_1_2_1_34_1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1523\/JNEUROSCI.11-02-00543.1991","article-title":"NGF rescues substance P expression but not neurofilament or tubulingene expression in axotomized sensory neurons","volume":"11","author":"Wong J","year":"1991","journal-title":"J Neurosci"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(88)90169-4"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90201-4"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.490350302","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.490350302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T17:47:43Z","timestamp":1695836863000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.490350302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,6,15]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,6,15]]}},"alternative-id":["10.1002\/jnr.490350302"],"URL":"https:\/\/doi.org\/10.1002\/jnr.490350302","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,6,15]]}}}