{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T19:24:24Z","timestamp":1769455464176,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":4089,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[1993,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We previously demonstrated that feeding rats Steenbock and Black's rickets\u2010inducing diet produces remarkable changes in the metabolic pattern of the in testinal mucosa, kidney, and liver and in some membrane transport Systems of intestinal mucosa and kidney. 1,25\u2010Dihydroxyvitamin D<jats:sub>3<\/jats:sub> administration to rachitic rats did not always prove to be effective in restoring normal values.<\/jats:p><jats:p>We have now investigated the effect of 1,25\u2010dihydroxyvitamin D<jats:sub>3<\/jats:sub> on the levels of some metabolites in rat cerebral cortex, on the activity of some enzymes, and on the transport of 2\u2010deoxy\u2010D\u2010glucose and D\u2010glucose in synaptosomes. Our experiments were carried out on three rat groups: control, rachitic, and rachitic treated with 1,25\u2010dihydroxyvitamin D<jats:sub>3<\/jats:sub>. The decrease in phosphorus content and the increase in citrate concentration observed in rachitic rat cerebral cortex were corrected by 1,25\u2010dihydroxyvitamin D<jats:sub>3<\/jats:sub> treatment.<\/jats:p><jats:p>The activity of acetylcholinesterase, glucose\u20106\u2010phosphate dehydrogenase, and acyl phosphatase significantly increased in rachitic rat synaptosomes, as well as NAD<jats:sup>+<\/jats:sup>\u2010dependent isocitrate dehydrogenase in cerebral cortex mitochondria; the administration of 1,25\u2010dihydroxyvitamin D<jats:sub>3<\/jats:sub> to rachitic rats restored enzyme levels to normal. The transport of 2\u2010deoxy\u2010D\u2010glucose and D\u2010glucose in rachitic rat synaptosomes was lower than in the control group and returned to control values in consequence of 1,25\u2010dihydroxyvitamin D<jats:sub>3<\/jats:sub> treatment.<\/jats:p><jats:p>The results reported here support the hypothesis of a participation of 1,25\u2010dihydroxyvitamin D<jats:sub>3<\/jats:sub> in some aspects of cerebral cortex metabolism.<\/jats:p>","DOI":"10.1002\/jnr.490350512","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T01:51:03Z","timestamp":1104544263000},"page":"559-566","source":"Crossref","is-referenced-by-count":17,"title":["Effect of vitamin D Deficiency and 1,25\u2010dihydroxyvitamin D<sub>3<\/sub> on metabolism and D\u2010glucose transport in rat cerebral cortex"],"prefix":"10.1002","volume":"35","author":[{"given":"M.","family":"Stio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Lunghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Lantomasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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