{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:06:25Z","timestamp":1777529185539,"version":"3.51.4"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":3997,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[1993,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The adult rat dorsal root ganglion (DRG) produces mRNA for the neurotrophic factors nerve growth factor (NGF) and brain\u2010derived neurotrophic factor (BDNF) and contains large populations of neurons responsive to these factors. We report that following a focal crush injury of the sciatic nerve, NGF mRNA expression increases threefold and BDNF mRNA twofold, in the ipsilateral L4 and L5 DRGs. The mRNAs encoding the cognate neurotrophin receptors, p75<jats:sup>NGFR<\/jats:sup>, trkA, and trkB were expressed in the DRG throughout the post\u2010injury time course, suggesting that DRG neurons remain responsive to both NGF and BDNF. p75<jats:sup>NGFR<\/jats:sup> mRNA levels became transiently depressed in the DRG during the first several days after the lesion but returned to normal within 1 week. <jats:italic>trk<\/jats:italic>B mRNA was expressed in the normal sciatic nerve and levels were not altered by nerve crush. RNase protection assays detected both full\u2010length and truncated <jats:italic>trk<\/jats:italic>B transcripts in the DRG, but only truncated <jats:italic>trk<\/jats:italic>B mRNA, lacking the tyrosine kinase domain, was detected in the sciatic nerve. Likewise, <jats:italic>trk<\/jats:italic>A transcripts were not detected by RNase protection in normal sciatic nerve or in a segment of nerve distal to the crush site. These results are consistent with a model in which regenerating sensory neurons are supported by neurotrophic factors synthesized within the DRG. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.490360402","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T01:54:28Z","timestamp":1104544468000},"page":"357-367","source":"Crossref","is-referenced-by-count":146,"title":["Expression of mRNA for neurotrophic factors and their receptors in the rat dorsal root ganglion and sciatic nerve following nerve injury"],"prefix":"10.1002","volume":"36","author":[{"given":"M. E.","family":"Sebert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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