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We demonstrate that rat oligodendrocyte\u2010type 2 astrocyte (O\u20102A) glial progenitor cells, precursors of the myelin\u2010forming cells in the CNS, express the transmembrane RTK <jats:italic>c<\/jats:italic>\u2010<jats:italic>kit<\/jats:italic>, the gene product of the murine dominant white spotting (W) locus and receptor for stem cell factor. Expression of <jats:italic>c<\/jats:italic>\u2010<jats:italic>kit<\/jats:italic> transcripts and immunoreactive protein is lost when O\u20102A progenitors differentiate into postmitotic oligodendrocytes. Analysis of developing rat brain revealed an increase in the expression of <jats:italic>c<\/jats:italic>\u2010<jats:italic>kit<\/jats:italic> transcripts between postnatal days 10 and 12, a window of time preceding the emergence of oligodendrocytes and the onset of myelination in vivo. Expression of <jats:italic>c<\/jats:italic>\u2010<jats:italic>kit<\/jats:italic> in vitro and in vivo suggests a role for this receptor and its ligand during oligodendrocyte development. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.490360512","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T01:54:30Z","timestamp":1104544470000},"page":"596-606","source":"Crossref","is-referenced-by-count":29,"title":["Expression of the receptor tyrosine kinase <i>c<\/i>\u2010<i>kit<\/i> in oligodendrocyte progenitor cells"],"prefix":"10.1002","volume":"36","author":[{"suffix":"Jr.","given":"J. A.","family":"Ida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Dubois\u2010Dalcq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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