{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T17:38:46Z","timestamp":1771004326044,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":3905,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[1994,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Leukemia inhibitory factor (LIF) has several characteristics of a neurotrophic factor for sensory neurons. Here we have investigated whether LIF also supports the survival of axotomised sensory neurons in vivo. Newborn rat pups received a unilateral sciatic nerve transection and the injury site was treated with gelfoam soaked in phosphate buffered saline (PBS), nerve growth factor (NGF), or LIF. Neuronal nucleoli in the L5 dorsal root ganglia were counted, appropriate corrections applied, and the resultant neuronal loss expressed as a percentage of the contralateral intact side. In animals where LIF was administered neuronal loss was significantly reduced: 2 days after LIF treatment neuronal loss was 19.5% compared to 43% in PBS\u2010treated animals; 3 days after LIF treatment neuronal loss was 20.4% compared to 40.2% in PBS\u2010treated animals; however, 7 days after LIF treatment there was no significant reduction in the number of neurons lost. The degree of rescue of sensory neurons in vivo by LIF was found to be similar to NGF, which was not surprising as both factors supported the survival of a similar population of sensory neurons in vitro. Rescue was not observed when LIF\u2010containing gelfoam was placed away from the axotomised nerve, suggesting that LIF's action may be associated with its retrograde transport or direct signalling at the site of nerve injury. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.490370207","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T01:55:33Z","timestamp":1104544533000},"page":"213-218","source":"Crossref","is-referenced-by-count":95,"title":["Leukemia inhibitory factor prevents the death of axotomised sensory neurons in the dorsal root ganglia of the neonatal rat"],"prefix":"10.1002","volume":"37","author":[{"given":"S. S.","family":"Cheema","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Richards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. F.","family":"Bartlett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/332360a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(88)90055-0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(89)90040-8"},{"key":"e_1_2_1_5_1","volume-title":"The Decade of the Brain","author":"Bartlett PF","year":"1991"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(92)90036-8"},{"key":"e_1_2_1_7_1","first-page":"617","article-title":"Axonal retrograde transport of CNTF; modulation by prior nerve injury and soluble CNTF receptor","volume":"18","author":"Curtis R","year":"1992","journal-title":"Soc Neurosci Abstr"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/326353a0"},{"key":"e_1_2_1_9_1","first-page":"617","article-title":"Axonal retrograde transport of CNTF and leukemia inhibitory factor (LIF) share a common receptor mechanism","volume":"18","author":"DiStefano PS","year":"1992","journal-title":"Soc Neurosci Abstr"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(92)90103-F"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-08-03241.1992"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(88)90013-1"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90116-U"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.06-08-02155.1986"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01175120"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-09-03427.1992"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90634-O"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(89)90127-9"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3798108"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90094-T"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.15.5948"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.8.3498"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1242\/dev.117.3.1173","article-title":"Involvement of leukemia inhibitory factor and nerve growth factor in the development of dorsal root ganglion neruons","volume":"117","author":"Murphy M","year":"1993","journal-title":"Development"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(89)90021-0"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2011743"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(87)90233-3"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490220111"},{"key":"e_1_2_1_28_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1242\/dev.112.1.83","article-title":"The effect of age on motor neuron death following axotomy in the mouse","volume":"112","author":"Polling MM","year":"1991","journal-title":"Development"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90083-C"},{"key":"e_1_2_1_30_1","first-page":"61","article-title":"Neuronal death after trophic factor deprivation","volume":"9","author":"Rich KM","year":"1992","journal-title":"J Neurotrauma"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01795309"},{"key":"e_1_2_1_32_1","first-page":"440","article-title":"Ciliary neurotrophic factor prevents the degeneration of motoneurons after axotomy","volume":"345","author":"Sendtner M","year":"1990","journal-title":"Science"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/358502a0"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.118.1.139"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(87)90708-7"},{"key":"e_1_2_1_36_1","first-page":"617","article-title":"Absence of both secretion and retrograde transport of ciliary neuronotrophic factor (CNTF) in peripheral nerves of the chick","volume":"3","author":"Smet PJ","year":"1992","journal-title":"Proc Aust Soc Neurosci"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.23.9231"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2512641"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/360753a0"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.04-12-02986.1984"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.490370207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.490370207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T13:19:08Z","timestamp":1698153548000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.490370207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,2]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,2]]}},"alternative-id":["10.1002\/jnr.490370207"],"URL":"https:\/\/doi.org\/10.1002\/jnr.490370207","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,2]]}}}